Description
NARS2 Antibody (PACO40138)
The NARS2 Polyclonal Antibody (PAC040138) is a crucial tool for researchers studying NARS2, a mitochondrial aminoacyl-tRNA synthetase enzyme essential for protein synthesis in mitochondria. This antibody, produced in rabbits, is highly specific to human samples and has been validated for Western blot applications. By targeting the NARS2 protein, this antibody allows for accurate detection and analysis in a variety of cell types, making it ideal for research in mitochondrial biology and related fields.NARS2 is a key player in mitochondrial protein synthesis and function, making it a valuable target for studying various mitochondrial-related diseases, including mitochondrial myopathy and respiratory chain deficiencies.
Understanding the role of NARS2 in mitochondrial function is crucial for developing potential treatments and therapies for these conditions. By using the NARS2 Polyclonal Antibody, researchers can further elucidate the mechanisms underlying mitochondrial protein synthesis and its implications in human health.
| Antibody Name: | NARS2 Antibody (PACO40138) |
| Antibody SKU: | PACO40138 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, IHC |
| Recommended Dilutions: | ELISA:1:2000-1:10000, IHC:1:20-1:200 |
| Species Reactivity: | Human |
| Immunogen: | Recombinant Human Probable asparagine--tRNA ligase, mitochondrial protein (15-210AA) |
| Form: | Liquid |
| Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
| Purification Method: | >95%, Protein G purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | Immunohistochemistry of paraffin-embedded human placenta tissue using PACO40138 at dilution of 1:100. |
 | Immunohistochemistry of paraffin-embedded human colon cancer using PACO40138 at dilution of 1:100. |
| Background: | mitochondrion, asparagine-tRNA ligase activity, asparaginyl-tRNA aminoacylation, gene expression, tRNA aminoacylation for protein translation |
| Synonyms: | Probable asparagine--tRNA ligase, mitochondrial (EC 6.1.1.22) (Asparaginyl-tRNA synthetase) (AsnRS), NARS2 |
| UniProt Protein Function: | NARS2: Belongs to the class-II aminoacyl-tRNA synthetase family. |
| UniProt Protein Details: | Protein type:Ligase; EC 6.1.1.22; Translation; Mitochondrial Chromosomal Location of Human Ortholog: 11q14.1 Cellular Component: mitochondrion Molecular Function:asparagine-tRNA ligase activity Biological Process: asparaginyl-tRNA aminoacylation Disease: Combined Oxidative Phosphorylation Deficiency 24 |
| NCBI Summary: | This gene encodes a putative member of the class II family of aminoacyl-tRNA synthetases. These enzymes play a critical role in protein biosynthesis by charging tRNAs with their cognate amino acids. This protein is encoded by the nuclear genome but is likely to be imported to the mitochondrion where it is thought to catalyze the ligation of asparagine to tRNA molecules. Mutations in this gene have been associated with combined oxidative phosphorylation deficiency 24 (COXPD24). [provided by RefSeq, Mar 2015] |
| UniProt Code: | Q96I59 |
| NCBI GenInfo Identifier: | 296452944 |
| NCBI Gene ID: | 79731 |
| NCBI Accession: | Q96I59.3 |
| UniProt Secondary Accession: | Q96I59,G3V178, |
| UniProt Related Accession: | Q96I59 |
| Molecular Weight: | 28,783 Da |
| NCBI Full Name: | Probable asparagine--tRNA ligase, mitochondrial |
| NCBI Synonym Full Names: | asparaginyl-tRNA synthetase 2, mitochondrial (putative) |
| NCBI Official Symbol: | NARS2Â Â |
| NCBI Official Synonym Symbols: | SLM5; asnRS; DFNB94Â Â |
| NCBI Protein Information: | probable asparagine--tRNA ligase, mitochondrial |
| UniProt Protein Name: | Probable asparagine--tRNA ligase, mitochondrial |
| UniProt Synonym Protein Names: | Asparaginyl-tRNA synthetase; AsnRS |
| UniProt Gene Name: | NARS2Â Â |
| UniProt Entry Name: | SYNM_HUMAN |
| Antibodies |
| NARS2 Antibody (PACO10735) |
| Secondary Antibody |
| Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
| Recommended Products |
| Anti-FITC Goat Anti-Rabbit IgG (H+L) Antibody (CABS011) |
| Anti-HRP-conjugated Beta Actin Antibody (CABC028) |
