The NCAPD3 Polyclonal Antibody (PAC015921) is a valuable tool for researchers studying NCAPD3, a key protein involved in the regulation of cell division and chromosome organization. This antibody, produced using rabbits as the host, is highly specific for human samples and has been validated for use in Western blot applications.NCAPD3, also known as non-SMC condensin II complex subunit D3, plays a crucial role in maintaining genome stability and ensuring accurate chromosome segregation during cell division. By targeting NCAPD3 with this antibody, researchers can gain insights into its function and potential implications in diseases such as cancer and genetic disorders.
The NCAPD3 Polyclonal Antibody is a reliable tool for detecting and studying NCAPD3 protein levels in various cell types, making it ideal for investigations into cell cycle regulation, mitosis, and chromatin organization. Its high specificity and sensitivity make it a valuable asset for studies in molecular biology, genetics, and cancer research. Unlock the potential of NCAPD3 research with this versatile antibody.
Antibody Name:
NCAPD3 Antibody (PACO15921)
Antibody SKU:
PACO15921
Size:
50ul
Host Species:
Rabbit
Tested Applications:
ELISA, IHC
Recommended Dilutions:
ELISA:1:2000-1:5000, IHC:1:50-1:200
Species Reactivity:
Human
Immunogen:
Fusion protein of human NCAPD3
Form:
Liquid
Storage Buffer:
-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Purification Method:
Antigen affinity purification
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using PACO15921(NCAPD3 Antibody) at dilution 1/50, on the right is treated with fusion protein. (Original magnification: x200).
The image on the left is immunohistochemistry of paraffin-embedded Human gastic cancer tissue using PACO15921(NCAPD3 Antibody) at dilution 1/50, on the right is treated with fusion protein. (Original magnification: x200).
Background:
Condensin complexes I and II play essential roles in mitotic chromosome assembly and segregation. Both condensins contain 2 invariant structural maintenance of chromosome (SMC) subunits, SMC2 and SMC4, but they contain different sets of non-SMC subunits. NCAPD3 is 1 of 3 non-SMC subunits that define condensin II.
Synonyms:
non-SMC condensin II complex, subunit D3
UniProt Protein Function:
NCAPD3: Regulatory subunit of the condensin-2 complex, a complex which establishes mitotic chromosome architecture and is involved in physical rigidity of the chromatid axis.Protein type: Cell cycle regulationChromosomal Location of Human Ortholog: 11q25Cellular Component: membrane; nucleoplasmMolecular Function: chromatin binding; methylated histone residue binding; protein bindingBiological Process: chromosome separation; meiotic chromosome condensation; mitotic chromosome condensation
UniProt Protein Details:
NCBI Summary:
Condensin complexes I and II play essential roles in mitotic chromosome assembly and segregation. Both condensins contain 2 invariant structural maintenance of chromosome (SMC) subunits, SMC2 (MIM 605576) and SMC4 (MIM 605575), but they contain different sets of non-SMC subunits. NCAPD3 is 1 of 3 non-SMC subunits that define condensin II (Ono et al., 2003 [PubMed 14532007]).[supplied by OMIM, Mar 2008]
