The NDN-L2 Polyclonal Antibody (PACO19227) is a valuable tool for researchers studying NDN-L2, a protein involved in neurodevelopmental disorders. This antibody, produced in rabbits, demonstrates high reactivity with human samples and has been validated for use in Western blot applications. By binding to the NDN-L2 protein, researchers can accurately detect and analyze its expression in various cell types, making it an essential tool for studies in neuroscience and developmental biology.NDN-L2, also known as necdin-like 2, is implicated in the regulation of neuronal development and has been linked to disorders affecting the nervous system.
Understanding the function of NDN-L2 is crucial for unraveling the complexities of neurodevelopment and identifying targets for therapeutic interventions in conditions like autism spectrum disorders and intellectual disabilities. By utilizing the NDN-L2 Polyclonal Antibody, researchers can further explore the role of this protein in normal brain development and pathological conditions.
The image on the left is immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using PACO19227(NDNL2 Antibody) at dilution 1/40, on the right is treated with synthetic peptide. (Original magnification: x200).
Gel: 10%SDS-PAGE, Lysate: 40 μg, Lane 1-4: Hela cells, human prostate tissue, A172 cells, mouse liver tissue tissue, Primary antibody: PACO19227(NDNL2 Antibody) at dilution 1/1500, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 40 seconds.
The image on the left is immunohistochemistry of paraffin-embedded Human breast cancer tissue using PACO19227(NDNL2 Antibody) at dilution 1/40, on the right is treated with synthetic peptide. (Original magnification: x200).
Background:
The protein encoded by this gene is part of the SMC5-6 chromatin reorganizing complex and is a member of the MAGE superfamily. This is an intronless gene. Component of the SMC5-SMC6 complex, a complex involved in repair of DNA double-strand breaks by homologous recombination. The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks. The complex is required for telomere maintenance via recombination in ALT (alternative lengthening of telomeres) cell lines and mediates sumoylation of shelterin complex (telosome) components which is proposed to lead to shelterin complex disassembly in ALT-associated PML bodies (APBs).
Synonyms:
necdin-like 2
UniProt Protein Function:
UniProt Protein Details:
NCBI Summary:
The protein encoded by this gene is part of the SMC5-6 chromatin reorganizing complex and is a member of the MAGE superfamily. This is an intronless gene. [provided by RefSeq, May 2011]
