The NEK11 Polyclonal Antibody (PAC010814) is a valuable tool for researchers studying NEK11, a protein kinase involved in cell cycle regulation and DNA damage response. This antibody, produced in rabbits, is highly specific to human NEK11 and has been validated for use in Western blot applications. By binding to NEK11, this antibody enables the detection and analysis of this protein in various cell types, making it an essential tool for studies in cell biology and cancer research.NEK11 is known to play a crucial role in maintaining genomic stability and cell division, making it a key target for research into understanding the mechanisms underlying cancer development and progression.
By studying NEK11 activity, researchers can gain insights into potential therapeutic strategies for cancers characterized by genomic instability, such as breast cancer and colorectal cancer. The NEK11 Polyclonal Antibody is a valuable resource for investigating the role of NEK11 in these contexts, ultimately leading to the development of novel treatment approaches.
NIMA (never in mitosis gene a)- related kinase 11;NEK11;FLJ23495 ;
UniProt Protein Function:
NEK11: Protein kinase which plays an important role in the G2/M checkpoint response to DNA damage. Controls degradation of CDC25A by directly phosphorylating it on residues whose phosphorylation is required for BTRC-mediated polyubiquitination and degradation. Interacts with isoform 1 of NEK2. Poorly expressed in cerebellum, trachea, lung, appendix, and uterus. Autorepressed by intramolecular binding of the C-terminus which dissociates following phosphorylation by NEK2 isoform 1 in G1/S-arrested cells. NEK2 isoform 2 is largely not present in the nucleolus, and does not appear to phosphorylate NEK11. Activated in response to DNA damage. Inhibited by zinc. Belongs to the protein kinase superfamily. NEK Ser/Thr protein kinase family. NIMA subfamily. 4 isoforms of the human protein are produced by alternative splicing.Protein type: Nucleolus; EC 2.7.11.1; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, Other; Other group; NEK familyChromosomal Location of Human Ortholog: 3q22.1Cellular Component: nucleolus; nucleoplasmMolecular Function: ATP binding; protein binding; protein serine/threonine kinase activityBiological Process: G2/M transition DNA damage checkpoint; histone phosphorylation; intra-S DNA damage checkpoint; protein amino acid phosphorylation
UniProt Protein Details:
NCBI Summary:
This gene encodes a member of the never in mitosis gene A family of kinases. The encoded protein localizes to the nucleoli, and may function with NEK2A in the S-phase checkpoint. The encoded protein appears to play roles in DNA replication and response to genotoxic stress. Alternatively spliced transcript variants have been described.[provided by RefSeq, Mar 2009]
