The NEMF Polyclonal Antibody (PAC020413) is a valuable tool for researchers studying NEMF, a protein involved in protein translation and quality control processes within the cell. This antibody, produced in rabbits, is highly specific for human samples and has been validated for use in Western blot applications. By targeting the NEMF protein, this antibody allows for accurate detection and analysis in a variety of cell types, making it ideal for research in molecular biology and protein synthesis pathways.NEMF, also known as ribosome-associated quality control complex subunit 6 (Rqc6), plays a crucial role in maintaining protein homeostasis by monitoring and degrading defective proteins during translation.
Dysregulation of NEMF has been linked to various diseases, including neurodegenerative disorders and cancer, highlighting its importance in cellular function and disease progression. By studying NEMF with this antibody, researchers can gain insights into its role in protein quality control mechanisms and its potential as a therapeutic target for diseases associated with protein misfolding and aggregation.
Antibody Name:
NEMF Antibody (PACO20413)
Antibody SKU:
PACO20413
Size:
50ul
Host Species:
Rabbit
Tested Applications:
ELISA, IHC
Recommended Dilutions:
ELISA:1:1000-1:2000, IHC:1:25-1:100
Species Reactivity:
Human
Immunogen:
Synthetic peptide of human NEMF
Form:
Liquid
Storage Buffer:
-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Purification Method:
Antigen affinity purification
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
The image on the left is immunohistochemistry of paraffin-embedded Human breast cancer tissue using PACO20413(NEMF Antibody) at dilution 1/30, on the right is treated with synthetic peptide. (Original magnification: x200).
The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using PACO20413(NEMF Antibody) at dilution 1/30, on the right is treated with synthetic peptide. (Original magnification: x200).
Background:
SDCCAG1, which called NY-CO-1, from a colon cancer cDNA library. The deduced 362-amino acid, protein contains a nuclear targeting signal. Expressed in brain, heart, liver, lung, spleen, and skeletal muscle. Also expressed at lower levels in stomach and testis.
Synonyms:
nuclear export mediator factor
UniProt Protein Function:
SDCCAG1: Plays a role in nuclear export. Belongs to the NEMF family. 5 isoforms of the human protein are produced by alternative splicing.
