The Neurl1 Antibody (PAC010823) is a highly specific tool for researchers studying Neurl1, a protein involved in neural development and synaptic function. This polyclonal antibody, generated in rabbits, is optimized for detecting Neurl1 in human samples and has been validated for use in Western blot applications.Neurl1 plays a crucial role in regulating the ubiquitination and degradation of proteins involved in neuronal development and synaptic plasticity. Dysregulation of Neurl1 has been associated with neurodevelopmental disorders and neurodegenerative diseases, making it a promising target for therapeutic intervention.
The Neurl1 Antibody enables researchers to investigate the expression and localization of Neurl1 in different cell types, providing insights into its roles in neural function and pathology. By understanding the function of Neurl1, researchers may uncover novel therapeutic strategies for treating neurological disorders.
NEURL1: May function as an E3 ubiquitin-protein ligase to activate monoubiquitination of JAG1, thereby regulating the Notch pathway. 2 isoforms of the human protein are produced by alternative splicing.Protein type: Tumor suppressor; Ubiquitin ligase; Ligase; Motility/polarity/chemotaxis; EC 6.3.2.-; Cell development/differentiation; Ubiquitin conjugating systemChromosomal Location of Human Ortholog: 10q25.1Cellular Component: dendritic spine; perikaryon; plasma membrane; postsynaptic densityMolecular Function: translation factor activity, non-nucleic acid binding; ubiquitin-protein ligase activityBiological Process: negative regulation of cell proliferation; negative regulation of Notch signaling pathway; nervous system development; positive regulation of apoptosis; positive regulation of filopodium formation; positive regulation of long-term neuronal synaptic plasticity; protein monoubiquitination
