Description
NF-kB p65/RelA Polyclonal Antibody (CAB22683)
The NF-κB p65/RelA Polyclonal Antibody (CAB22683) is a valuable tool for researchers studying NF-κB signaling pathways and transcriptional regulation. NF-κB is a key transcription factor involved in a wide range of cellular processes, including immune responses, inflammation, and cell survival. This antibody, produced in rabbits, specifically targets the p65 subunit of NF-κB, enabling precise detection and analysis in various experimental settings.The NF-κB p65/RelA Polyclonal Antibody is highly reactive with human samples and has been validated for use in Western blot applications, making it an essential reagent for researchers in the fields of immunology, cancer biology, and inflammation.
By targeting the p65 subunit, this antibody allows for the investigation of NF-κB activation and its downstream effects, shedding light on the molecular mechanisms underlying various diseases and conditions.With its ability to specifically detect and bind to the NF-κB p65 subunit, the CAB22683 antibody is a powerful tool for exploring the intricate regulation of NF-κB signaling and its implications for health and disease. Researchers can leverage this antibody to uncover new insights into the role of NF-κB in cellular processes and to advance the development of targeted therapies for conditions characterized by dysregulated NF-κB activity.
| Product Name: | NF-kB p65/RelA Polyclonal Antibody |
| Product Code: | CAB22683 |
| Reactivity: | Human, Mouse, Rat |
| Applications: | Western blotting, Immunohistochemistry, Immunofluorescence |
| Host Species: | Rabbit |
| Purification Method: | Affinity purification |
| Isotype: | IgG |
| Reactivity: | Human, Mouse, Rat |
| Tested Applications: | WB, IHC-P, IF/ICC, ELISA |
| Key Applications: | Western blotting, Immunohistochemistry, Immunofluorescence |
| Recommended Dilution: | WB 1:2000-1:10000, IHC-P 1:100-1:500, IF/ICC 1:100-1:500 |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300, 50% glycerol, pH7.3. |
| Positive Samples: | HeLa, COS-7, NIH/3T3, Mouse lung, PC-12 |
| Cellular Location: | cytoplasm, cytosol, glutamatergic synapse, nucleoplasm, nucleus |
NF-kappa-B is a ubiquitous transcription factor involved in several biological processes. It is held in the cytoplasm in an inactive state by specific inhibitors. Upon degradation of the inhibitor, NF-kappa-B moves to the nucleus and activates transcription of specific genes. NF-kappa-B is composed of NFKB1 or NFKB2 bound to either REL, RELA, or RELB. The most abundant form of NF-kappa-B is NFKB1 complexed with the product of this gene, RELA. Four transcript variants encoding different isoforms have been found for this gene.
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 450-551 of human NF-kB p65/RelA. (NP_068810.3). |
| Sequence: | LGALL GNSTD PAVFT DLASV DNSEF QQLLN QGIPV APHTT EPMLM EYPEA ITRLV TGAQR PPDPA PAPLG APGLP NGLLS GDEDF SSIAD MDFSA LLSQI SS |
| Synonyms: | p65, CMCU, NFKB3, AIF3BL3 |
| Calculated MW: | 60kDa |
| Observed MW: | 65kDa |
