Description
NFKBID Antibody (PACO13939)
The NFKBID Polyclonal Antibody (PAC013939) is a valuable tool for researchers studying NFKBID, a key regulator of the NF-kappa-B signaling pathway. This antibody, developed in rabbits, exhibits high specificity for human samples and is optimized for Western blot applications. By binding to the NFKBID protein, this antibody enables researchers to accurately detect and analyze NFKBID expression in a variety of cell types, making it an indispensable asset for studies in immunology and cancer research.NFKBID, also known as I-kappa-B-zeta, plays a crucial role in modulating immune responses by controlling the activation of NF-kappa-B, a transcription factor involved in inflammation, immunity, and cell survival.
Dysregulation of the NF-kappa-B signaling pathway is associated with various diseases, including cancer, autoimmune disorders, and inflammatory conditions. Therefore, investigating the function of NFKBID is essential for developing targeted therapies that can modulate immune responses in these pathological contexts.By utilizing the NFKBID Polyclonal Antibody (PAC013939), researchers can gain valuable insights into the role of NFKBID in immune regulation and disease pathogenesis, paving the way for the development of novel therapeutic strategies aimed at restoring immune homeostasis and combating immune-related disorders.
| Antibody Name: | NFKBID Antibody (PACO13939) |
| Antibody SKU: | PACO13939 |
| Size: | 50ul |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB, IHC |
| Recommended Dilutions: | ELISA:1:1000-1:5000, WB:1:200-1:1000, IHC:1:25-1:100 |
| Species Reactivity: | Human, Mouse |
| Immunogen: | Fusion protein of human NFKBID |
| Form: | Liquid |
| Storage Buffer: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
| Purification Method: | Antigen affinity purification |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using PACO13939(NFKBID Antibody) at dilution 1/40, on the right is treated with fusion protein. (Original magnification: x200). |
 | Gel: 10+12%SDS-PAGE, Lysate: 40 μg, Lane: RAW264.7 cells, Primary antibody: PACO13939(NFKBID Antibody) at dilution 1/650, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 2 minutes. |
 | The image on the left is immunohistochemistry of paraffin-embedded Human colon cancer tissue using PACO13939(NFKBID Antibody) at dilution 1/40, on the right is treated with fusion protein. (Original magnification: x200). |
| Background: | May regulate the expression of IL-2, IL-6, and other cytokines through regulation on NF-kappa-B activity. Functions in the regulation of inflammatory responses. May also regulate TCR-induced negative selection of thymocytes.I κ BNS, the nuclear I κ B-like protein encoded by Nfkbid, is required for the development of marginal zone and peritoneal B-1 B cells and additionally required for extrafollicular antibody responses to T-independent and -dependent immunogens.I κ BNS has been identified as a member of the I κ B family of NF- κ B inhibitors, which undergoes induction upon TCR signaling. I κ BNS mediates both positive and negative gene regulation, depending on individual cell type and/or cytokine. |
| Synonyms: | nuclear factor of κ light polypeptide gene enhancer in B-cells inhibitor, delta |
| UniProt Protein Function: | NFKBID: May regulate the expression of IL-2, IL-6, and other cytokines through regulation on NF-kappa-B activity. Functions in the regulation of inflammatory responses. May also regulate TCR- induced negative selection of thymocytes. Belongs to the NF-kappa-B inhibitor family. 3 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Chromosomal Location of Human Ortholog: 19q13.12 Cellular Component: nucleus Molecular Function:NF-kappaB binding Biological Process: inhibition of NF-kappaB transcription factor; negative regulation of T cell differentiation in the thymus; negative regulation of I-kappaB kinase/NF-kappaB cascade; inflammatory response |
| UniProt Code: | Q8NI38 |
| NCBI GenInfo Identifier: | 74751323 |
| NCBI Gene ID: | 84807 |
| NCBI Accession: | Q8NI38.1 |
| UniProt Secondary Accession: | Q8NI38,Q8NI39, Q9BRG9, |
| UniProt Related Accession: | Q8NI38 |
| Molecular Weight: | 150 |
| NCBI Full Name: | NF-kappa-B inhibitor delta |
| NCBI Synonym Full Names: | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, delta |
| NCBI Official Symbol: | NFKBIDÂ Â |
| NCBI Official Synonym Symbols: | TA-NFKBH; IkappaBNSÂ Â |
| NCBI Protein Information: | NF-kappa-B inhibitor delta; ikB-delta; ikappaBdelta; I-kappa-B-delta; T-cell activation NFKB-like protein |
| UniProt Protein Name: | NF-kappa-B inhibitor delta |
| UniProt Synonym Protein Names: | I-kappa-B-delta; IkB-delta; IkappaBdelta; IkappaBNS; T-cell activation NFKB-like protein; TA-NFKBH |
| Protein Family: | NF-kappa-B inhibitor |
| UniProt Gene Name: | NFKBIDÂ Â |
| UniProt Entry Name: | IKBD_HUMAN |
