The NLRP9 Antibody (PAC020105) is a highly specific tool for research involving NLRP9, an important member of the NOD-like receptor family implicated in the regulation of inflammation and innate immune responses. This polyclonal antibody, raised in rabbits, is specifically designed for use in various applications such as Western blotting and immunofluorescence.NLRP9 is known to play a crucial role in the activation of the inflammasome, a multiprotein complex involved in the maturation and secretion of pro-inflammatory cytokines. Dysregulation of NLRP9 has been linked to various inflammatory disorders and autoimmune diseases, making it a key target for therapeutic interventions.
By utilizing the NLRP9 Antibody, researchers can effectively study the function and expression of NLRP9 in different cellular contexts, advancing our understanding of its role in health and disease. Overall, the NLRP9 Antibody is a valuable tool for investigators in the fields of immunology, inflammation, and infectious diseases, providing reliable and accurate detection of NLRP9 for groundbreaking research discoveries.
Antibody Name:
NLRP9 Antibody (PACO20105)
Antibody SKU:
PACO20105
Size:
50ul
Host Species:
Rabbit
Tested Applications:
ELISA, IHC
Recommended Dilutions:
ELISA:1:2000-1:5000, IHC:1:50-1:200
Species Reactivity:
Human
Immunogen:
Synthetic peptide of human NLRP9
Form:
Liquid
Storage Buffer:
-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Purification Method:
Antigen affinity purification
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
The image on the left is immunohistochemistry of paraffin-embedded Human brain tissue using PACO20105(NLRP9 Antibody) at dilution 1/40, on the right is treated with synthetic peptide. (Original magnification: x200).
The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using PACO20105(NLRP9 Antibody) at dilution 1/40, on the right is treated with synthetic peptide. (Original magnification: x200).
Background:
The protein encoded by this gene belongs to the NALP protein family. Members of the NALP protein family typically contain a NACHT domain, a NACHT-associated domain (NAD), a C-terminal leucine-rich repeat (LRR) region, and an N-terminal pyrin domain (PYD). This protein may play a regulatory role in the innate immune system as similar family members belong to the signal-induced multiprotein complex, the inflammasome, that activates the pro-inflammatory caspases, caspase-1 and caspase-5.
Synonyms:
NLR family, pyrin domain containing 9
UniProt Protein Function:
NLRP9: Involved in inflammation (Potential). Belongs to the NLRP family. 2 isoforms of the human protein are produced by alternative splicing.Chromosomal Location of Human Ortholog: 19q13.42Cellular Component: cytoplasmMolecular Function: ATP binding
UniProt Protein Details:
NCBI Summary:
The protein encoded by this gene belongs to the NALP protein family. Members of the NALP protein family typically contain a NACHT domain, a NACHT-associated domain (NAD), a C-terminal leucine-rich repeat (LRR) region, and an N-terminal pyrin domain (PYD). This protein may play a regulatory role in the innate immune system as similar family members belong to the signal-induced multiprotein complex, the inflammasome, that activates the pro-inflammatory caspases, caspase-1 and caspase-5. [provided by RefSeq, Jul 2008]
NACHT, LRR and PYD domains-containing protein 9; PYRIN and NACHT-containing protein 12; NACHT, LRR and PYD containing protein 9; NACHT, leucine rich repeat and PYD containing 9; nucleotide-binding oligomerization domain protein 6; nucleotide-binding oligomerization domain, leucine rich repeat and pyrin domain containing 9
UniProt Protein Name:
NACHT, LRR and PYD domains-containing protein 9
UniProt Synonym Protein Names:
Nucleotide-binding oligomerization domain protein 6; PYRIN and NACHT-containing protein 12
