The NLRP9 Polyclonal Antibody (PAC020106) is specifically designed for research involving NLRP9, a member of the NOD-like receptor (NLR) family implicated in regulating immune responses and inflammatory processes. The antibody, produced in rabbits, is highly reactive with human samples and has been validated for use in Western blot and immunohistochemistry applications.NLRP9 plays a critical role in the activation of the inflammasome, a multiprotein complex involved in the production of pro-inflammatory cytokines. It is thought to be involved in the immune response to pathogens and in the development of inflammatory disorders.
Research into NLRP9 function is important for understanding how the immune system responds to various stimuli and for the development of new therapies targeting inflammatory diseases.The NLRP9 Polyclonal Antibody enables the detection and analysis of NLRP9 protein expression in different cell types, making it an ideal tool for studies in immunology and inflammatory disease research. By investigating the role of NLRP9 in immune regulation, researchers can gain valuable insights into the mechanisms underlying immune responses and potentially identify new therapeutic targets for treating inflammatory conditions.
Antibody Name:
NLRP9 Antibody (PACO20106)
Antibody SKU:
PACO20106
Size:
50ul
Host Species:
Rabbit
Tested Applications:
ELISA, IHC
Recommended Dilutions:
ELISA:1:1000-1:2000, IHC:1:25-1:100
Species Reactivity:
Human
Immunogen:
Synthetic peptide of human NLRP9
Form:
Liquid
Storage Buffer:
-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Purification Method:
Antigen affinity purification
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
The image on the left is immunohistochemistry of paraffin-embedded Human gastic cancer tissue using PACO20106(NLRP9 Antibody) at dilution 1/40, on the right is treated with synthetic peptide. (Original magnification: x200).
Background:
The protein encoded by this gene belongs to the NALP protein family. Members of the NALP protein family typically contain a NACHT domain, a NACHT-associated domain (NAD), a C-terminal leucine-rich repeat (LRR) region, and an N-terminal pyrin domain (PYD). This protein may play a regulatory role in the innate immune system as similar family members belong to the signal-induced multiprotein complex, the inflammasome, that activates the pro-inflammatory caspases, caspase-1 and caspase-5.
Synonyms:
NLR family, pyrin domain containing 9
UniProt Protein Function:
NLRP9: Involved in inflammation (Potential). Belongs to the NLRP family. 2 isoforms of the human protein are produced by alternative splicing.Chromosomal Location of Human Ortholog: 19q13.42Cellular Component: cytoplasmMolecular Function: ATP binding
UniProt Protein Details:
NCBI Summary:
The protein encoded by this gene belongs to the NALP protein family. Members of the NALP protein family typically contain a NACHT domain, a NACHT-associated domain (NAD), a C-terminal leucine-rich repeat (LRR) region, and an N-terminal pyrin domain (PYD). This protein may play a regulatory role in the innate immune system as similar family members belong to the signal-induced multiprotein complex, the inflammasome, that activates the pro-inflammatory caspases, caspase-1 and caspase-5. [provided by RefSeq, Jul 2008]
NACHT, LRR and PYD domains-containing protein 9; PYRIN and NACHT-containing protein 12; NACHT, LRR and PYD containing protein 9; NACHT, leucine rich repeat and PYD containing 9; nucleotide-binding oligomerization domain protein 6; nucleotide-binding oligomerization domain, leucine rich repeat and pyrin domain containing 9
UniProt Protein Name:
NACHT, LRR and PYD domains-containing protein 9
UniProt Synonym Protein Names:
Nucleotide-binding oligomerization domain protein 6; PYRIN and NACHT-containing protein 12
