Description
NMD3 Antibody (PACO10872)
The NMD3 Polyclonal Antibody (PACO10872) is a valuable tool for researchers studying NMD3, a protein involved in the regulation of ribosome biogenesis and export from the nucleus to the cytoplasm. This antibody, generated in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications.NMD3 is essential for protein synthesis and cellular growth, making it an important target for investigation in molecular biology and cancer research. By binding specifically to NMD3, this antibody allows for the detection and analysis of NMD3 protein levels in various cell types, aiding in the exploration of its function and potential therapeutic applications.
The role of NMD3 in ribosome assembly and nucleo-cytoplasmic transport makes it a key player in cellular processes that are often dysregulated in cancer cells. Research into the function of NMD3 may provide insights into mechanisms of tumorigenesis and suggest novel strategies for treating cancer by targeting this pathway. The NMD3 Polyclonal Antibody is a valuable tool for scientists aiming to better understand the role of NMD3 in disease and cellular biology.
| Antibody Name: | NMD3 Antibody (PACO10872) |
| Antibody SKU: | PACO10872 |
| Size: | 50ul |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB |
| Recommended Dilutions: | |
| Species Reactivity: | Human, Mouse, Rat |
| Immunogen: | Human NMD3 |
| Form: | Liquid |
| Storage Buffer: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles. |
| Purification Method: | Antigen Affinity purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
| Synonyms: | NMD3 homolog (S. cerevisiae);NMD3;CGI-07;FLJ21053 ; |
| UniProt Protein Function: | NMD3: Acts as an adapter for the XPO1/CRM1-mediated export of the 60S ribosomal subunit. Belongs to the NMD3 family. |
| UniProt Protein Details: | Protein type:Nucleolus; Adaptor/scaffold Chromosomal Location of Human Ortholog: 3q26.1 Cellular Component: nucleoplasm; membrane; cytoplasm; nucleolus; nucleus Molecular Function:protein binding, bridging; ribosomal large subunit binding Biological Process: protein transport; ribosomal large subunit export from nucleus |
| NCBI Summary: | Ribosomes are composed of 60S and 40S subunits that are assembled in the nucleolus and exported to the cytoplasm through nuclear pore complexes in the nuclear envelope. NMD3 is an adaptor for 60S subunit export via the CRM1 (XPO1; MIM 602559) pathway (Trotta et al., 2003 [PubMed 12773398]).[supplied by OMIM, Mar 2008] |
| UniProt Code: | Q96D46 |
| NCBI GenInfo Identifier: | 74731412 |
| NCBI Gene ID: | 51068 |
| NCBI Accession: | Q96D46.1 |
| UniProt Secondary Accession: | Q96D46,Q9Y2Z6, D3DNM7, |
| UniProt Related Accession: | Q96D46 |
| Molecular Weight: | 503 |
| NCBI Full Name: | 60S ribosomal export protein NMD3 |
| NCBI Synonym Full Names: | NMD3 ribosome export adaptor |
| NCBI Official Symbol: | NMD3Â Â |
| NCBI Official Synonym Symbols: | CGI-07Â Â |
| NCBI Protein Information: | 60S ribosomal export protein NMD3; hNMD3; NMD3 homolog |
| UniProt Protein Name: | 60S ribosomal export protein NMD3 |
| Protein Family: | 60S ribosomal export protein |
| UniProt Gene Name: | NMD3Â Â |
| UniProt Entry Name: | NMD3_HUMAN |
