The NOL8 Polyclonal Antibody (PACO10890) is a cutting-edge tool designed for researchers studying NOL8, a key player in RNA processing and ribosome biogenesis. This antibody, produced in rabbits, exhibits high specificity and sensitivity when detecting NOL8 in human samples, making it an essential asset for experiments involving Western blot applications.NOL8, also known as nucleolar protein 8, is a critical component in the regulation of ribosomal RNA synthesis and processing, as well as in the assembly of ribosomes.
Its involvement in these fundamental cellular processes positions it as a target of interest for investigations into areas such as gene expression regulation, cell growth, and development. By using the NOL8 Polyclonal Antibody, researchers can gain valuable insights into the function and expression patterns of NOL8 in various cell types, paving the way for advancements in molecular biology and cancer research.
nucleolar protein 8;NOL8;C9orf34;DKFZp686P12242;FLJ20736;Nop132;bA62C3.3;bA62C3.4 ;
UniProt Protein Function:
NOL8: Plays an essential role in the survival of diffuse-type gastric cancer cells. Acts as a nucleolar anchoring protein for DDX47. May be involved in regulation of gene expression at the post-transcriptional level or in ribosome biogenesis in cancer cells. 4 isoforms of the human protein are produced by alternative splicing.Protein type: Nucleolus; RNA-bindingChromosomal Location of Human Ortholog: 9q22.31Cellular Component: cytoplasm; nucleolus; nucleusMolecular Function: nucleotide binding; protein bindingBiological Process: DNA replication; positive regulation of cell growth; rRNA processing
UniProt Protein Details:
NCBI Summary:
NOL8 binds Ras-related GTP-binding proteins (see MIM 608267) and plays a role in cell growth (Sekiguchi et al., 2004 [PubMed 14660641]).[supplied by OMIM, Mar 2008]
