The NOM1 Antibody (PACO05039) is a valuable tool for research involving NOM1, a protein involved in ribosome biogenesis and nucleolar function. This polyclonal antibody, raised in rabbits, is highly specific and reactive with human samples, making it ideal for a variety of research applications.NOM1 is crucial for the assembly and maturation of ribosomes, which are essential for protein synthesis. Dysregulation of ribosome biogenesis has been linked to a wide range of diseases, including cancer and neurodegenerative disorders.
By targeting NOM1 with this antibody, researchers can investigate its role in these diseases and potentially develop targeted therapies.This antibody is validated for use in Western blotting, immunofluorescence, and immunoprecipitation, allowing for detailed analysis of NOM1 expression and localization in various cell types. Its high specificity and sensitivity make it a reliable tool for studying the function of NOM1 in cellular processes and disease mechanisms.
Antibody Name:
NOM1 Antibody (PACO05039)
Antibody SKU:
PACO05039
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA, IHC
Recommended Dilutions:
ELISA:1:40000, IHC:1:100-1:300
Species Reactivity:
Human, Mouse
Immunogen:
Synthesized peptide derived from the C-terminal region of human NOM1.
Form:
Liquid
Storage Buffer:
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification Method:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
Synonyms:
NOM1; C7orf3; Nucleolar MIF4G domain-containing protein 1; SGD1 homolog
UniProt Protein Function:
NOM1: a nucleolar protein that binds eIF4A and encoded within the chromosome 7q36 breakpoint region associated with pediatric acute myeloid leukemia. Contains an MIF4G and an MA3 domain. MIF4G and MA3 domains bind proteins of the eIF4A family of ATP-dependent DEAD-box RNA helicases required for both translation and nonsense-mediated decay. MIF4G domains are found in several proteins involved in RNA metabolism, including eIF4G, eIF-2b, UPF2, and nuclear cap-binding proteins.Protein type: Nucleolus; Unknown functionChromosomal Location of Human Ortholog: 7q36.3Cellular Component: nucleolus; nucleusMolecular Function: protein binding
UniProt Protein Details:
NCBI Summary:
Proteins that contain MIF4G (middle of eIF4G (MIM 600495)) and/or MA3 domains, such as NOM1, function in protein translation. These domains include binding sites for members of the EIF4A family of ATP-dependent DEAD box RNA helicases (see EIF4A1; MIM 602641) (Simmons et al., 2005 [PubMed 15715967]).[supplied by OMIM, Mar 2008]
