The NPTX2 Antibody (CAB12031) is a high-quality antibody developed for reliable detection and analysis of target proteins. This antibody, generated in rabbits, exhibits high specificity and sensitivity for detecting NPTX2 in human samples, making it ideal for use in Western blot applications.NPTX2, also known as neuronal pentraxin 2, is involved in mediating synaptic transmission and plasticity, playing a crucial role in cognitive function and memory formation. Dysregulation of NPTX2 has been linked to neurological disorders such as Alzheimer's disease and epilepsy, highlighting its importance in brain health and function.
This antibody is validated for use in WB, ELISA applications and has demonstrated reactivity against Human samples.
Product Name:
NPTX2 Antibody
SKU:
CAB12031
Size:
20μL, 100μL
Reactivity:
Human
Conjugate:
Unconjugated
Immunogen:
Recombinant protein (or fragment).This information is considered to be commercially sensitive.
Recommended starting concentration is 1 μg/mL. Please optimize the concentration based on your specific assay requirements.
Synonyms:
NP2, NARP, NP-II, NPTX2
Positive Sample:
SH-SY5Y, BxPC-3, LO2
Cellular Localization:
Secreted.
Calculated MW:
47kDa
Observed MW:
47kDa
This gene encodes a member of the family of neuronal petraxins, synaptic proteins that are related to C-reactive protein. This protein is involved in excitatory synapse formation. It also plays a role in clustering of alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA)-type glutamate receptors at established synapses, resulting in non-apoptotic cell death of dopaminergic nerve cells. Up-regulation of this gene in Parkinson disease (PD) tissues suggests that the protein may be involved in the pathology of PD.
Purification Method
Affinity purification
Gene ID
4885
RRID
AB_2758942
Buffer Information
Store at -20℃. Avoid freeze / thaw cycles. Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using NPTX2 Rabbit pAb (CAB12031) at 1:3000 dilution. Secondary antibody: HRP-conjugated Goat anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25μg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (AbGn00020). Exposure time: 60s.
