Description
NRG2 Antibody (PACO28650)
The NRG2 Antibody (PAC028650) is a highly specific and sensitive tool for studying Neuregulin 2 (NRG2), a critical protein involved in cell-to-cell communication and signaling in the brain. This polyclonal antibody is raised in rabbits and has been validated for use in various research applications, including Western blot analysis.NRG2 is known to play a key role in neural development, synaptic plasticity, and cognitive function, making it a crucial target for studies in neuroscience and neurobiology. By targeting NRG2 with this antibody, researchers can investigate the function and regulation of this important protein in normal brain function and disease states.
With its high reactivity and specificity for human samples, the NRG2 Antibody (PAC028650) is a valuable tool for researchers looking to deepen their understanding of NRG2 and its role in brain development, function, and disease. This antibody enables precise detection and analysis of NRG2 in various experimental settings, providing insights that can potentially lead to the development of novel therapeutic strategies for neurological disorders.
| Antibody Name: | NRG2 Antibody (PACO28650) |
| Antibody SKU: | PACO28650 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB, IHC, IF |
| Recommended Dilutions: | ELISA:1:2000-1:10000, WB:1:500-1:2000, IHC:1:20-1:200, IF:1:50-1:200 |
| Species Reactivity: | Human |
| Immunogen: | Recombinant Human Pro-neuregulin-2, membrane-bound isoform protein (112-405AA) |
| Form: | Liquid |
| Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
| Purification Method: | >95%, Protein G purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | Western blot All lanes: NRG2 antibody at 16µg/ml + U251 whole cell lysate Secondary Goat polyclonal to rabbit IgG at 1/10000 dilution Predicted band size: 92, 91, 93, 47, 46, 68, 71 kDa Observed band size: 92 kDa . |
 | Immunofluorescent analysis of PC-3 cells using PACO28650 at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L). |
 | Immunohistochemistry of paraffin-embedded human lung cancer using PACO28650 at dilution of 1:100. |
| Background: | Direct ligand for ERBB3 and ERBB4 tyrosine kinase receptors. Concomitantly recruits ERBB1 and ERBB2 coreceptors, resulting in ligand-stimulated tyrosine phosphorylation and activation of the ERBB receptors. May also promote the heterodimerization with the EGF receptor. |
| Synonyms: | Pro-neuregulin-2, membrane-bound isoform (Pro-NRG2) [Cleaved into: Neuregulin-2 (NRG-2) (Divergent of neuregulin-1) (DON-1) (Neural- and thymus-derived activator for ERBB kinases) (NTAK)], NRG2, NTAK |
| UniProt Protein Function: | NRG2: Direct ligand for ERBB3 and ERBB4 tyrosine kinase receptors. Concomitantly recruits ERBB1 and ERBB2 coreceptors, resulting in ligand-stimulated tyrosine phosphorylation and activation of the ERBB receptors. May also promote the heterodimerization with the EGF receptor. Belongs to the neuregulin family. 8 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Ligand, receptor tyrosine kinase; Membrane protein, integral Chromosomal Location of Human Ortholog: 5q31.2 Cellular Component: extracellular space; extracellular region; plasma membrane; integral to membrane Molecular Function:growth factor activity; receptor binding Biological Process: epidermal growth factor receptor signaling pathway; embryonic development; phosphoinositide-mediated signaling; fibroblast growth factor receptor signaling pathway; nerve growth factor receptor signaling pathway; organ development; innate immune response; signal transduction |
| NCBI Summary: | This gene encodes a novel member of the neuregulin family of growth and differentiation factors. Through interaction with the ERBB family of receptors, this protein induces the growth and differentiation of epithelial, neuronal, glial, and other types of cells. The gene consists of 12 exons and the genomic structure is similar to that of neuregulin 1, another member of the neuregulin family of ligands. The products of these genes mediate distinct biological processes by acting at different sites in tissues and eliciting different biological responses in cells. This gene is located close to the region for demyelinating Charcot-Marie-Tooth disease locus, but is not responsible for this disease. Alternative transcript variants encoding distinct isoforms have been described. [provided by RefSeq, May 2010] |
| UniProt Code: | O14511 |
| NCBI GenInfo Identifier: | 3914154 |
| NCBI Gene ID: | 9542 |
| NCBI Accession: | O14511.1 |
| UniProt Related Accession: | O14511 |
| Molecular Weight: | 70,637 Da |
| NCBI Full Name: | Pro-neuregulin-2, membrane-bound isoform |
| NCBI Synonym Full Names: | neuregulin 2 |
| NCBI Official Symbol: | NRG2Â Â |
| NCBI Official Synonym Symbols: | DON1; HRG2; NTAKÂ Â |
| NCBI Protein Information: | pro-neuregulin-2, membrane-bound isoform; pro-NRG2; divergent of neuregulin-1; neural- and thymus-derived activator for ErbB kinases |
| UniProt Protein Name: | Pro-neuregulin-2, membrane-bound isoform |
| UniProt Synonym Protein Names: | Divergent of neuregulin-1; DON-1; Neural- and thymus-derived activator for ERBB kinases; NTAK |
| Protein Family: | Pro-neuregulin |
| UniProt Gene Name: | NRG2Â Â |
| UniProt Entry Name: | NRG2_HUMAN |
| Antibodies | ELISA Kits |
| NRG2 Antibody (PACO01927) | Human NRG-2 / Neuregulin 2 ELISA Kit |
| Human NRG-2 (Neuregulin 2) CLIA Kit (HUES00539) | |
| Human NRG-2 (Neuregulin 2) ELISA Kit (HUES02025) |
| Secondary Antibody |
| Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
| Recommended Products |
| Anti-FITC Goat Anti-Rabbit IgG (H+L) Antibody (CABS011) |
| Anti-HRP-conjugated Beta Actin Antibody (CABC028) |
