The NT5C1A Polyclonal Antibody (PAC040734) is a valuable tool for researchers studying NT5C1A, a key enzyme involved in nucleotide metabolism and cellular signaling pathways. This antibody, generated in rabbits, is highly specific for human NT5C1A and has been validated for use in Western blotting and immunofluorescence applications. By binding to the NT5C1A protein, this antibody allows for precise detection and analysis in a variety of cell types, making it an essential component for studies in molecular biology and cancer research.NT5C1A is known for its role in maintaining cellular nucleotide pools and regulating purinergic signaling, making it a potential target for therapeutic interventions in conditions such as cancer and neurological disorders.
By understanding the function and regulation of NT5C1A, researchers can gain valuable insights into its potential as a biomarker or therapeutic target in various diseases. The NT5C1A Polyclonal Antibody is a powerful tool for uncovering the complexities of NT5C1A biology and its implications in human health and disease.
Immunohistochemistry of paraffin-embedded human kidney tissue using PACO40734 at dilution of 1:10.
Immunofluorescent analysis of A549 cells using PACO40734 at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
Background:
Dephosphorylates the 5' and 2'(3')-phosphates of deoxyribonucleotides and has a broad substrate specificity. Helps to regulate adenosine levels in heart during ischemia and hypoxia.
NT5C1A: Dephosphorylates the 5' and 2'(3')-phosphates of deoxyribonucleotides and has a broad substrate specificity. Helps to regulate adenosine levels in heart during ischemia and hypoxia. Belongs to the 5'-nucleotidase type 3 family.Protein type: Nucleotide Metabolism - purine; Nucleotide Metabolism - pyrimidine; Cofactor and Vitamin Metabolism - nicotinate and nicotinamide; EC 3.1.3.5; Phosphatase (non-protein)Chromosomal Location of Human Ortholog: 1p34.3-p33Cellular Component: cytosolMolecular Function: 5'-nucleotidase activity; magnesium ion binding; nucleotide bindingBiological Process: adenosine metabolic process; dephosphorylation; nucleobase, nucleoside and nucleotide metabolic process; nucleoside metabolic process; purine base metabolic process; purine nucleoside monophosphate catabolic process; purine nucleotide catabolic process; pyrimidine base metabolic process; pyrimidine nucleoside catabolic process
UniProt Protein Details:
NCBI Summary:
Cytosolic nucleotidases, such as NT5C1A, dephosphorylate nucleoside monophosphates (Hunsucker et al., 2001 [PubMed 11133996]).[supplied by OMIM, Mar 2008]
