Description
NTSR2 Antibody (PACO54922)
The NTSR2 Polyclonal Antibody (PAC054922) is a valuable tool for researchers studying NTSR2, a neurotensin receptor involved in a variety of physiological processes. This rabbit-raised antibody exhibits high reactivity with human samples and is specifically validated for use in Western blot applications. By binding to the NTSR2 protein, this antibody enables the detection and analysis of NTSR2 in various cell types, making it an ideal choice for studies in neuroscience and pharmacology.NTSR2, a G protein-coupled receptor for the neuropeptide neurotensin, plays a crucial role in modulating neurotransmission, pain perception, and gastrointestinal function.
Its involvement in these processes makes it a potential target for research on conditions such as chronic pain, neurodegenerative disorders, and gastrointestinal diseases. Understanding the function of NTSR2 is key to developing innovative treatments that target this receptor and its signaling pathways.Overall, the NTSR2 Polyclonal Antibody (PAC054922) is a valuable tool for researchers looking to investigate the role of NTSR2 in various physiological processes and diseases, paving the way for new insights and potential therapeutic interventions.
| Antibody Name: | NTSR2 Antibody (PACO54922) |
| Antibody SKU: | PACO54922 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB, IHC, IF |
| Recommended Dilutions: | ELISA:1:2000-1:10000, WB:1:500-1:5000, IHC:1:20-1:200, IF:1:50-1:200 |
| Species Reactivity: | Human |
| Immunogen: | Recombinant Human Neurotensin receptor type 2 protein (359-410AA) |
| Form: | Liquid |
| Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
| Purification Method: | >95%, Protein G purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | Western Blot. Positive WB detected in: U87 whole cell lysate. All lanes: NTSR2 antibody at 3.2µg/ml. Secondary. Goat polyclonal to rabbit IgG at 1/50000 dilution. Predicted band size: 46 kDa. Observed band size: 46 kDa. |
 | Immunohistochemistry of paraffin-embedded human prostate tissue using PACO54922 at dilution of 1:100. |
 | Immunohistochemistry of paraffin-embedded human adrenal gland tissue using PACO54922 at dilution of 1:100. |
| Background: | Receptor for the tridecapeptide neurotensin. It is associated with G proteins that activate a phosphatidylinositol-calcium second messenger system. |
| Synonyms: | Neurotensin receptor type 2 (NT-R-2) (NTR2) (Levocabastine-sensitive neurotensin receptor), NTSR2 |
| UniProt Protein Function: | NTSR2: neurotensin receptor 2 |
| UniProt Protein Details: | Protein type:Membrane protein, integral; Receptor, GPCR; GPCR, family 1; Membrane protein, multi-pass Chromosomal Location of Human Ortholog: 2p25.1 Cellular Component: integral to plasma membrane; plasma membrane Molecular Function:G-protein coupled receptor activity; neurotensin receptor activity, G-protein coupled Biological Process: regulation of membrane potential; cell surface receptor linked signal transduction; neuropeptide signaling pathway; sensory perception; G-protein signaling, coupled to IP3 second messenger (phospholipase C activating) |
| NCBI Summary: | The protein encoded by this gene belongs to the G protein-coupled receptor family that activate a phosphatidylinositol-calcium second messenger system. Binding and pharmacological studies demonstrate that this receptor binds neurotensin as well as several other ligands already described for neurotensin NT1 receptor. However, unlike NT1 receptor, this gene recognizes, with high affinity, levocabastine, a histamine H1 receptor antagonist previously shown to compete with neurotensin for low-affinity binding sites in brain. These activities suggest that this receptor may be of physiological importance and that a natural agonist for the receptor may exist. [provided by RefSeq, Jul 2008] |
| UniProt Code: | O95665 |
| NCBI GenInfo Identifier: | 311033404 |
| NCBI Gene ID: | 23620 |
| NCBI Accession: | O95665.2 |
| UniProt Related Accession: | O95665 |
| Molecular Weight: | |
| NCBI Full Name: | Neurotensin receptor type 2 |
| NCBI Synonym Full Names: | neurotensin receptor 2 |
| NCBI Official Symbol: | NTSR2Â Â |
| NCBI Official Synonym Symbols: | NTR2Â Â |
| NCBI Protein Information: | neurotensin receptor type 2 |
| UniProt Protein Name: | Neurotensin receptor type 2 |
| UniProt Synonym Protein Names: | Levocabastine-sensitive neurotensin receptor |
| Protein Family: | Thioredoxin reductase |
| UniProt Gene Name: | NTSR2Â Â |
| UniProt Entry Name: | NTR2_HUMAN |
| Antibodies |
| NTSR2 Antibody (PACO03730) |
| Secondary Antibody |
| Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
| Recommended Products |
| Anti-FITC Goat Anti-Rabbit IgG (H+L) Antibody (CABS011) |
| Anti-HRP-conjugated Beta Actin Antibody (CABC028) |
