The NXF3 Polyclonal Antibody (PACO04760) is a valuable tool for researchers studying NXF3, a nuclear RNA export factor involved in mRNA transport from the nucleus to the cytoplasm. This antibody, produced in rabbits, exhibits high specificity and sensitivity for human samples, making it ideal for Western blot applications.NXF3 plays a crucial role in the regulation of gene expression by facilitating the export of mature mRNA molecules. Dysregulation of NXF3 has been implicated in various diseases, including cancer and neurodegenerative disorders, making it a promising target for therapeutic intervention.
By using the NXF3 Polyclonal Antibody, researchers can analyze the expression levels and localization of NXF3 in different cell types, providing insights into its function in RNA transport and gene expression regulation. This antibody is a valuable tool for studies in molecular biology, cancer research, and neurobiology, offering new opportunities for understanding the role of NXF3 in health and disease.
Antibody Name:
NXF3 Antibody
Antibody SKU:
PACO04760
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA, WB, IHC
Recommended Dilutions:
WB:1:500-1:2000, IHC:1:100-1:300
Species Reactivity:
Human
Immunogen:
synthesized peptide derived from the Internal region of human NXF3.
Form:
Liquid
Storage Buffer:
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification Method:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
NXF3: May function as a tissue-specific nuclear mRNA export factor. Belongs to the NXF family.Chromosomal Location of Human Ortholog: Xq22Cellular Component: cytoplasm; nuclear RNA export factor complex; nucleoplasm; nucleusMolecular Function: mRNA binding; nucleotide binding; protein bindingBiological Process: mRNA export from nucleus; poly(A)+ mRNA export from nucleus
UniProt Protein Details:
NCBI Summary:
This gene is one member of a family of nuclear RNA export factor genes. Common domain features of this family are a noncanonical RNP-type RNA-binding domain (RBD), 4 leucine-rich repeats (LRRs), a nuclear transport factor 2 (NTF2)-like domain that allows heterodimerization with NTF2-related export protein-1 (NXT1), and a ubiquitin-associated domain that mediates interactions with nucleoporins. The LRRs and NTF2-like domains are required for export activity. Alternative splicing seems to be a common mechanism in this gene family. The encoded protein of this gene has shortened LRR and ubiquitin-associated domains and its RDB is unable to bind RNA. It is located in the nucleoplasm but is not associated with either the nuclear envelope or the nucleolus. [provided by RefSeq, Jul 2008]
