The Obscurin Polyclonal Antibody (CAB18110) is a valuable tool for researchers studying the protein obscurin, a large sarcomeric protein found in striated muscle. This rabbit polyclonal antibody is highly specific and reactive with human samples, making it ideal for use in Western blot applications to detect and analyze obscurin in various cell types.Obscurin is known for its role in sarcomere organization and muscle function, and abnormalities in obscurin have been linked to cardiac and skeletal muscle diseases.
By using the Obscurin Polyclonal Antibody, researchers can further investigate the function of obscurin in muscle biology and pathology, making it a valuable resource for studies in muscle physiology, cardiac development, and muscle-related disorders.Overall, the Obscurin Polyclonal Antibody is a reliable tool for researchers looking to explore the role of obscurin in muscle biology and disease, providing valuable insights into the mechanisms underlying muscle function and dysfunction.
Product Name:
OBSCN Rabbit Polyclonal Antibody
SKU:
CAB18110
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1621-1710 of human OBSCN (NP_443075.3).
cytosol, M band, myofibril, nuclear body, plasma membrane, sarcolemma, Z disc
Calculated MW:
868kDa
Observed MW:
Refer to figures
The obscurin gene spans more than 150 kb, contains over 80 exons and encodes a protein of approximately 720 kDa. The encoded protein contains 68 Ig domains, 2 fibronectin domains, 1 calcium/calmodulin-binding domain, 1 RhoGEF domain with an associated PH domain, and 2 serine-threonine kinase domains. This protein belongs to the family of giant sacromeric signaling proteins that includes titin and nebulin, and may have a role in the organization of myofibrils during assembly and may mediate interactions between the sarcoplasmic reticulum and myofibrils. Alternatively spliced transcript variants encoding different isoforms have been identified.
Purification Method:
Affinity purification
Gene ID:
84033
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Immunofluorescence analysis of U-2 OS cells using OBSCN Rabbit pAb (CAB18110) at dilution of 1:100. Secondary antibody: Cy3 Goat Anti-Rabbit IgG (H+L) (CABS007) at 1:500 dilution. Blue: DAPI for nuclear staining.
