The OLFM3 Polyclonal Antibody (PAC016812) is a powerful tool for researchers studying OLFM3, a protein involved in various biological processes such as cell adhesion, migration, and signaling. This antibody, produced in rabbits, exhibits strong reactivity with human samples and is validated for use in Western blot applications. By specifically binding to the OLFM3 protein, researchers can accurately detect and analyze its expression in different cell types, making it an essential tool for studies in cell biology and cancer research.OLFM3, also known as olfactomedin 3, is a key player in cellular interactions and signaling pathways that are crucial for normal development and tissue homeostasis.
Its involvement in promoting or inhibiting cell functions makes it a promising target for investigating diseases such as cancer, neurodegenerative disorders, and cardiovascular conditions. Understanding the role of OLFM3 can provide valuable insights into the mechanisms underlying these diseases and pave the way for potential therapeutic interventions aimed at modulating its activity.
Antibody Name:
OLFM3 Antibody (PACO16812)
Antibody SKU:
PACO16812
Size:
50ul
Host Species:
Rabbit
Tested Applications:
ELISA, WB
Recommended Dilutions:
ELISA:1:1000-1:2000, WB:1:200-1:1000
Species Reactivity:
Human, Mouse, Rat
Immunogen:
Fusion protein of human OLFM3
Form:
Liquid
Storage Buffer:
-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Purification Method:
Antigen affinity purification
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
Gel: 6%SDS-PAGE, Lysate: 40 μg, Lane: Mouse intestines tissue, Primary antibody: PACO16812(OLFM3 Antibody) at dilution 1/200, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 2 minutes.
Background:
OLFM3 (olfactomedin 3), also known as NOE3, is a 478 amino acid, protein that interacts with myocilin. Myocilin is an extracellular protein that plays a key role in the actomyosin system and is responsible for controlling intraocular pressure. OLFM3 is a secreted protein that contains an olfactomedin-like (OLF) domain, an approximately 260 amino acid, motif commonly found in secreted glycoproteins. OLFM3 localizes to the Golgi apparatus of the cell and is highly expressed in both eye and brain tissue. Mutations in the gene that encodes OLFM3 may cause severe glaucoma, a condition in which increased intraocular pressure within the eyeball causes loss of eye sight.
Synonyms:
olfactomedin 3
UniProt Protein Function:
OLFM3: 6 isoforms of the human protein are produced by alternative splicing.Protein type: Secreted; Secreted, signal peptideChromosomal Location of Human Ortholog: 1p22Molecular Function: protein binding
