The Protein OS-9 Polyclonal Antibody (CAB12261) is a valuable tool for researchers studying OS-9, a protein involved in ER-associated protein degradation and quality control mechanisms in the cell. This antibody, generated in rabbits, exhibits high reactivity with human samples and is validated for use in Western blot applications.OS-9 is known to play a crucial role in the recognition and degradation of misfolded proteins in the endoplasmic reticulum, a process essential for maintaining cellular homeostasis and preventing the accumulation of toxic protein aggregates. Dysregulation of ER quality control mechanisms, including those involving OS-9, has been implicated in various diseases, such as neurodegenerative disorders and certain cancers.
By targeting the OS-9 protein, researchers can investigate its functions in different cell types and explore its potential therapeutic implications in diseases characterized by protein misfolding and aggregation. The Protein OS-9 Polyclonal Antibody (CAB12261) provides a reliable tool for detecting and studying OS-9 in the context of protein quality control pathways, making it an invaluable resource for research in cell biology, molecular biology, and disease mechanisms.
Product Name:
OS9 Rabbit Polyclonal Antibody
SKU:
CAB12261
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 353-612 of human OS9 (NP_001017956.1).
This gene encodes a protein that is highly expressed in osteosarcomas. This protein binds to the hypoxia-inducible factor 1 (HIF-1), a key regulator of the hypoxic response and angiogenesis, and promotes the degradation of one of its subunits. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.
Purification Method:
Affinity purification
Gene ID:
10956
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using OS9 Rabbit pAb (CAB12261) at 1:3000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 15s.
