The P2RY13 Polyclonal Antibody (PAC040306) is a valuable tool for researchers studying P2RY13, a G protein-coupled receptor known to be involved in immune regulation and inflammation. This antibody, raised in rabbits, is highly specific to human samples and has been validated for use in Western blot applications. It binds specifically to the P2RY13 protein, allowing for detection and analysis in a variety of cell types.P2RY13 is a key player in immune response modulation, making it a promising target for research in areas such as immunology, inflammation, and neurology.
By understanding the role of P2RY13 in various diseases and conditions, researchers can potentially develop new therapies and treatment strategies. This antibody provides a reliable tool for studying the function and expression of P2RY13 in different biological contexts, aiding in the advancement of knowledge in this field.
Western blot. All lanes: P2RY13 antibody at 3µg/ml. Lane 1: HT29 whole cell lysate. Lane 2: Colo320 whole cell lysate. Secondary. Goat polyclonal to rabbit IgG at 1/10000 dilution. Predicted band size: 41, 39 kDa. Observed band size: 41 kDa.
Immunofluorescent analysis of HepG2 cells using PACO40306 at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
Background:
Receptor for ADP. Coupled to G(i)-proteins. May play a role in hematopoiesis and the immune system.
P2RY13: Receptor for ADP. Coupled to G(i)-proteins. May play a role in hematopoiesis and the immune system. Belongs to the G-protein coupled receptor 1 family. 2 isoforms of the human protein are produced by alternative splicing.Protein type: Membrane protein, integral; Receptor, GPCR; Membrane protein, multi-pass; GPCR, family 1Chromosomal Location of Human Ortholog: 3q24Cellular Component: endoplasmic reticulum; integral to plasma membrane; plasma membraneMolecular Function: purinergic nucleotide receptor activity, G-protein coupledBiological Process: negative regulation of adenylate cyclase activity
UniProt Protein Details:
NCBI Summary:
The product of this gene belongs to the family of G-protein coupled receptors. This family has several receptor subtypes with different pharmacological selectivity, which overlaps in some cases, for various adenosine and uridine nucleotides. This receptor is activated by ADP. [provided by RefSeq, Sep 2008]
