The PACS2 Monoclonal Antibody (PAC013556) is a valuable tool for researchers studying the role of PACS2, a protein involved in intracellular trafficking and autophagy. This antibody, produced in a monoclonal format, is highly specific to human samples and has been validated for use in immunofluorescence and immunohistochemistry applications.PACS2 is a key player in maintaining cellular homeostasis by regulating organelle dynamics and protein sorting pathways. Dysregulation of PACS2 has been linked to various diseases, including neurodegenerative disorders and cancer.
By targeting PACS2 with this antibody, researchers can study its function and potential therapeutic implications in these pathological conditions.Overall, the PACS2 Monoclonal Antibody is a valuable resource for investigating the molecular mechanisms underlying PACS2 function in cellular processes and disease development. Its specificity and reliability make it a crucial tool for advancing research in cell biology, neurology, and oncology.
phosphofurin acid, c cluster sorting protein 2;PACS2;FLJ25488;KIAA0602;PACS1L ;
UniProt Protein Function:
PACS2: Multifunctional sorting protein that controls the endoplasmic reticulum (ER)-mitochondria communication, including the apposition of mitochondria with the ER and ER homeostasis. In addition, in response to apoptic inducer, translocates BIB to mitochondria, which initiates a sequence of events including the formation of mitochondrial truncated BID, the release of cytochrome c, the activation of caspase-3 thereby causing cell death. May also be involved in ion channel trafficking, directing acidic cluster-containing ion channels to distinct subcellular compartments. Belongs to the PACS family. 3 isoforms of the human protein are produced by alternative splicing.Chromosomal Location of Human Ortholog: 14q32.33Cellular Component: endoplasmic reticulumBiological Process: autophagic vacuole formation
