The PALB2 Antibody (CAB8373) is a high-quality antibody developed for reliable detection and analysis of target proteins. This antibody, generated in rabbits, exhibits high reactivity with human samples and has been validated for use in a variety of applications, including Western blotting.PALB2, a tumor suppressor gene, plays a crucial role in the repair of DNA double-strand breaks and in maintaining chromosomal integrity. Mutations in PALB2 have been linked to an increased risk of breast and ovarian cancer, making it an important target for cancer research.
This antibody is validated for use in WB, ELISA applications and has demonstrated reactivity against Human samples.
Product Name:
PALB2 Antibody
SKU:
CAB8373
Size:
20μL, 100μL
Reactivity:
Human
Conjugate:
Unconjugated
Immunogen:
Recombinant protein (or fragment).This information is considered to be commercially sensitive.
Recommended starting concentration is 1 μg/mL. Please optimize the concentration based on your specific assay requirements.
Synonyms:
FANCN, PNCA3, PALB2
Positive Sample:
Jurkat, 293T
Cellular Localization:
Nucleus.
Calculated MW:
131kDa
Observed MW:
150kDa
This gene encodes a protein that may function in tumor suppression. This protein binds to and colocalizes with the breast cancer 2 early onset protein (BRCA2) in nuclear foci and likely permits the stable intranuclear localization and accumulation of BRCA2.
Purification Method
Affinity purification
Gene ID
79728
RRID
AB_2770779
Buffer Information
Store at -20℃. Avoid freeze / thaw cycles. Buffer: PBS containing 50% glycerol, preserved with proclin300 or sodium azide, pH 7.3.
Western blot analysis of various lysates using PALB2 Rabbit pAb (CAB8373) at 1:1000 dilution. Secondary antibody: HRP-conjugated Goat anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25μg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (AbGn00020). Exposure time: 60s.
