Description
PANK1 Antibody (PACO28798)
The PANK1 Polyclonal Antibody (PAC028798) is a valuable tool for researchers studying PANK1, an enzyme involved in the biosynthesis of coenzyme A, a crucial molecule in various metabolic pathways. This antibody, produced in rabbits, exhibits high reactivity specifically with human samples and is validated for use in Western blot applications.PANK1 is known to play a key role in regulating cellular metabolism and energy production, making it a potential target for investigating metabolic disorders and related diseases. By binding to the PANK1 protein, this antibody enables researchers to detect and analyze its expression in different cell types, offering insights into its functions and potential therapeutic applications.
Research involving PANK1 is important for understanding the intricate mechanisms underlying metabolic regulation and identifying new strategies for managing metabolic diseases such as diabetes, obesity, and cardiovascular disorders. This antibody is an essential tool for scientists conducting studies in the fields of metabolism, biochemistry, and drug development.
| Antibody Name: | PANK1 Antibody (PACO28798) |
| Antibody SKU: | PACO28798 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, IHC, IF |
| Recommended Dilutions: | ELISA:1:2000-1:10000, IHC:1:20-1:200, IF:1:50-1:200 |
| Species Reactivity: | Human |
| Immunogen: | Recombinant Human Pantothenate kinase 1 protein (462-582AA) |
| Form: | Liquid |
| Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
| Purification Method: | >95%, Protein G purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | Immunohistochemistry of paraffin-embedded human testis tissue using PACO28798 at dilution of 1:100. |
 | Immunofluorescent analysis of HepG2 cells using PACO28798 at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L). |
| Background: | Plays a role in the physiological regulation of the intracellular CoA concentration. |
| Synonyms: | Pantothenate kinase 1 (hPanK) (hPanK1) (EC 2.7.1.33) (Pantothenic acid, kinase 1), PANK1, PANK |
| UniProt Protein Function: | PANK1: Plays a role in the physiological regulation of the intracellular CoA concentration. Belongs to the type II pantothenate kinase family. 4 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Cofactor and Vitamin Metabolism - pantothenate and CoA biosynthesis; EC 2.7.1.33; Kinase, other Chromosomal Location of Human Ortholog: 10q23.31 Cellular Component: recycling endosome; clathrin coat; nucleus; cytosol Molecular Function:pantothenate kinase activity; ATP binding Biological Process: coenzyme biosynthetic process; coenzyme A biosynthetic process; vitamin metabolic process; pantothenate metabolic process; phosphorylation; water-soluble vitamin metabolic process |
| NCBI Summary: | This gene encodes a member of the pantothenate kinase family. Pantothenate kinases are key regulatory enzymes in the biosynthesis of coenzyme A (CoA). The encoded protein catalyzes the first and rate-limiting enzymatic reaction in CoA biosynthesis and is regulated by CoA through feedback inhibition. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. This gene and an intronic miRNA on the same strand are co-regulated by the tumor suppressor p53 (see PMID 20833636). [provided by RefSeq, Apr 2011] |
| UniProt Code: | Q8TE04 |
| NCBI GenInfo Identifier: | 27805665 |
| NCBI Gene ID: | 53354 |
| NCBI Accession: | Q8TE04.2 |
| UniProt Secondary Accession: | Q8TE04,Q7RTX6, Q7Z495, Q8TBQ8, A6NIP0, |
| UniProt Related Accession: | Q8TE04 |
| Molecular Weight: | 598 |
| NCBI Full Name: | Pantothenate kinase 1 |
| NCBI Synonym Full Names: | pantothenate kinase 1 |
| NCBI Official Symbol: | PANK1Â Â |
| NCBI Official Synonym Symbols: | PANKÂ Â |
| NCBI Protein Information: | pantothenate kinase 1; pantothenic acid kinase 1 |
| UniProt Protein Name: | Pantothenate kinase 1 |
| UniProt Synonym Protein Names: | Pantothenic acid kinase 1 |
| Protein Family: | Pantothenate kinase |
| UniProt Gene Name: | PANK1Â Â |
| UniProt Entry Name: | PANK1_HUMAN |
| Antibodies |
| PANK1 Antibody (PACO11064) |
| Secondary Antibody |
| Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
| Recommended Products |
| Anti-FITC Goat Anti-Rabbit IgG (H+L) Antibody (CABS011) |
| Anti-HRP-conjugated Beta Actin Antibody (CABC028) |
