The PASD1 Polyclonal Antibody (PACO37834) is specially designed for researchers studying PASD1, a protein associated with cancer. This antibody, produced in rabbits, is highly specific for detecting PASD1 in human samples and has been validated for use in Western blot assays. By binding to the PASD1 protein, this antibody allows for accurate detection and analysis in various cell types, making it an essential tool for studies in oncology and cancer research.
PASD1 is a promising target for cancer research due to its role in tumorigenesis and its potential as a therapeutic target. Understanding the expression and function of PASD1 is crucial for developing new strategies for diagnosing and treating cancer. The PASD1 Polyclonal Antibody offers researchers a reliable tool for investigating the molecular mechanisms underlying cancer development and progression, ultimately contributing to advances in cancer therapy.
Antibody Name:
PASD1 Antibody (PACO37834)
Antibody SKU:
PACO37834
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA, WB
Recommended Dilutions:
ELISA:1:2000-1:10000, WB:1:500-1:2000
Species Reactivity:
Human
Immunogen:
Recombinant Human Circadian clock protein PASD1 protein (301-600AA)
Western blot. All lanes: PASD1 antibody at 4µg/ml + A549 whole cell lysate. Secondary. Goat polyclonal to rabbit IgG at 1/10000 dilution. Predicted band size: 88, 73 kDa. Observed band size: 88 kDa.
Background:
Functions as a suppressor of the biological clock that drives the daily circadian rhythms of cells throughout the body. Acts as a nuclear repressor of the CLOCK-ARNTL/BMAL1 heterodimer-mediated transcriptional activation of the core clock components. Inhibits circadian clock function in cancer cells, when overexpressed.
Synonyms:
Circadian clock protein PASD1 (Cancer/testis antigen 63) (CT63) (OX-TES-1) (PAS domain-containing protein 1), PASD1
UniProt Protein Function:
PASD1: May function as a transcription factor. 2 isoforms of the human protein are produced by alternative splicing.Protein type: Cancer Testis Antigen (CTA)Chromosomal Location of Human Ortholog: Xq28Cellular Component: nucleoplasm; nucleusBiological Process: negative regulation of circadian rhythm; negative regulation of transcription, DNA-dependent
UniProt Protein Details:
NCBI Summary:
This gene encodes a protein that is thought to function as a transcription factor. The protein is a cancer-associated antigen that can stimulate autologous T-cell responses, and it is therefore considered to be a potential immunotherapeutic target for the treatment of various hematopoietic malignancies, including diffuse large B-cell lymphoma. [provided by RefSeq, May 2010]
