The PCDHAC1 Polyclonal Antibody (PACO20184) is a powerful tool for researchers studying PCDHAC1, a cell adhesion molecule known to play a role in various cellular processes including cell recognition and signaling. This antibody, generated in rabbits, exhibits strong reactivity towards human samples and has been validated for use in Western blot applications.PCDHAC1, a member of the protocadherin family, is involved in cell-cell adhesion and communication, making it a key player in development and tissue organization. Its implications in cancer progression and neuronal development make it a fascinating research target for scientists exploring the mechanisms behind these processes.
With the ability to specifically bind to the PCDHAC1 protein, this antibody enables accurate detection and analysis of PCDHAC1 expression in a variety of cell types. Its versatility and reliability make it an ideal tool for studies in developmental biology, cancer research, and neurobiology, providing valuable insights into the role of PCDHAC1 in health and disease.
The image on the left is immunohistochemistry of paraffin-embedded Human colon cancer tissue using PACO20184(PCDHAC1 Antibody) at dilution 1/50, on the right is treated with synthetic peptide. (Original magnification: x200).
Gel: 6%SDS-PAGE, Lysate: 40 µg, Lane: K562 cells, Primary antibody: PACO20184(PCDHAC1 Antibody) at dilution 1/200, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 1 minute.
The image on the left is immunohistochemistry of paraffin-embedded Human brain tissue using PACO20184(PCDHAC1 Antibody) at dilution 1/50, on the right is treated with synthetic peptide. (Original magnification: x200).
Background:
This gene is a member of the protocadherin α gene cluster, one of three related gene clusters tandemly linked on chromosome five that demonstrate an unusual genomic organization similar to that of B-cell and T-cell receptor gene clusters. The α gene cluster is composed of 15 cadherin superfamily genes related to the mouse CNR genes and consists of 13 highly similar and 2 more distantly related coding sequences.
Synonyms:
protocadherin α subfamily C, 1
UniProt Protein Function:
PCDHAC1: Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain. 2 isoforms of the human protein are produced by alternative splicing.Protein type: Membrane protein, integralChromosomal Location of Human Ortholog: 5q31Cellular Component: integral to plasma membraneMolecular Function: calcium ion bindingBiological Process: nervous system development; cell adhesion; homophilic cell adhesion
UniProt Protein Details:
NCBI Summary:
This gene is a member of the protocadherin alpha gene cluster, one of three related gene clusters tandemly linked on chromosome five that demonstrate an unusual genomic organization similar to that of B-cell and T-cell receptor gene clusters. The alpha gene cluster is composed of 15 cadherin superfamily genes related to the mouse CNR genes and consists of 13 highly similar and 2 more distantly related coding sequences. The tandem array of 15 N-terminal exons, or variable exons, are followed by downstream C-terminal exons, or constant exons, which are shared by all genes in the cluster. The large, uninterrupted N-terminal exons each encode six cadherin ectodomains while the C-terminal exons encode the cytoplasmic domain. These neural cadherin-like cell adhesion proteins are integral plasma membrane proteins that most likely play a critical role in the establishment and function of specific cell-cell connections in the brain. Alternative splicing has been observed and additional variants have been suggested but their full-length nature has yet to be determined. [provided by RefSeq, Jul 2008]
