The PCDHGB7 Polyclonal Antibody (PAC06455) is a valuable tool for researchers studying the PCDHGB7 protein, a member of the cadherin superfamily involved in cell-cell adhesion and signaling processes. This antibody is produced in rabbits and has been specifically validated for use in immunohistochemistry and immunofluorescence applications. PCDHGB7, also known as protocadherin gamma subfamily B, member 7, plays a critical role in neuronal development and synaptic plasticity. Its expression in the brain suggests involvement in neuronal connectivity and function, making it a target of interest in neuroscience research. The PCDHGB7 Polyclonal Antibody enables researchers to detect and visualize PCDHGB7 protein localization in tissue samples, providing valuable insights into its function and potential implications in neurodevelopmental disorders and neurological diseases.
By studying the role of PCDHGB7, researchers can gain a better understanding of how cadherin proteins contribute to brain development and function, paving the way for potential therapeutic strategies targeting neurological disorders. The PCDHGB7 Polyclonal Antibody offers high specificity and sensitivity, making it a reliable tool for investigating the functions of PCDHGB7 in various biological contexts.
Antibody Name:
PCDHGB7 Antibody (PACO64455)
Antibody SKU:
PACO64455
Size:
50ul
Host Species:
Rabbit
Tested Applications:
ELISA, IF
Recommended Dilutions:
IF:1:100-1:500
Species Reactivity:
Human
Immunogen:
Recombinant Human Protocadherin gamma-B7 protein (719-929AA)
Immunofluorescence staining of SH-SY5Y cells with PACO64455 at 1:200, counter-stained with DAPI. The cells were fixed in 4% formaldehyde and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
Background:
Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain.
Synonyms:
Protocadherin gamma-B7 (PCDH-gamma-B7), PCDHGB7
UniProt Protein Function:
Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain.
UniProt Protein Details:
NCBI Summary:
This gene is a member of the protocadherin gamma gene cluster, one of three related clusters tandemly linked on chromosome five. These gene clusters have an immunoglobulin-like organization, suggesting that a novel mechanism may be involved in their regulation and expression. The gamma gene cluster includes 22 genes divided into 3 subfamilies. Subfamily A contains 12 genes, subfamily B contains 7 genes and 2 pseudogenes, and the more distantly related subfamily C contains 3 genes. The tandem array of 22 large, variable region exons are followed by a constant region, containing 3 exons shared by all genes in the cluster. Each variable region exon encodes the extracellular region, which includes 6 cadherin ectodomains and a transmembrane region. The constant region exons encode the common cytoplasmic region. These neural cadherin-like cell adhesion proteins most likely play a critical role in the establishment and function of specific cell-cell connections in the brain. Alternative splicing has been described for the gamma cluster genes. [provided by RefSeq, Jul 2008]
