The PCP4 Polyclonal Antibody (PAC013790) is a valuable tool for researchers studying the protein PCP4, which plays a role in neuronal development and function. This antibody is produced in rabbits and has been shown to exhibit high reactivity with human samples, making it a reliable choice for Western blot applications. By binding to the PCP4 protein, this antibody enables accurate detection and analysis in a variety of cell types, making it an essential tool for studies in neurobiology and neuroscience.
PCP4, also known as Purkinje Cell Protein 4, is involved in the regulation of calcium signaling and gene expression in the brain. Its functions in neuronal development and synaptic transmission make it a key target for research into conditions such as neurodegenerative diseases and cognitive disorders. By studying the role of PCP4, researchers can gain insights into the mechanisms underlying these conditions and potentially identify new therapeutic strategies for treating them.
The image on the left is immunohistochemistry of paraffin-embedded Human tonsil tissue using PACO13790(PCP4 Antibody) at dilution 1/50, on the right is treated with fusion protein. (Original magnification: x200).
Gel: 12%SDS-PAGE, Lysate: 40 μg, Lane: Mouse brain tissue, Primary antibody: PACO13790(PCP4 Antibody) at dilution 1/1000, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 2 minutes.
The image on the left is immunohistochemistry of paraffin-embedded Human cervical cancer tissue using PACO13790(PCP4 Antibody) at dilution 1/50, on the right is treated with fusion protein. (Original magnification: x200).
Background:
PCP-4 (Purkinje cell protein 4), also known as PEP-19, is a calmodulin (CaM) regulatory protein that is highly expressed in neuronal cells. Through its IQ motif, PCP-4 mediates both the calcium-dependent binding properties of CaM and the rates of association and dissociation of calcium from the C-terminal domain of CaM. The IQ motif contains a serine residue which can be phosphorylated by all isoforms of protein kinase C (PKC). PCP-4 is implicated in uterine leiomyomas, as well as in neurodegenerative disorders such as AlzheimerÂ’s disease and Huntington's disease. Additionally, overexpression of PCP-4 is thought to play a role in cerebellar hypoplasia, a key feature of Down syndrome.
Synonyms:
purkinje cell protein 4
UniProt Protein Function:
PCP4: Probable regulator of calmodulin signaling. Belongs to the PCP4 family.Protein type: Cell development/differentiation; Calcium-bindingChromosomal Location of Human Ortholog: 21q22.2Cellular Component: cytosol; nucleusMolecular Function: calmodulin bindingBiological Process: central nervous system development
