The PDZD2 Antibody (PACO03681) is a highly specific and sensitive tool designed for research involving PDZD2, a protein involved in synaptic transmission and neuronal development. This polyclonal antibody, generated in rabbits, is optimized for detection of PDZD2 in human samples and has been validated for use in various applications, including Western blotting.PDZD2 is a scaffolding protein that plays a crucial role in organizing protein complexes at the synapse, contributing to the regulation of neurotransmission and synaptic plasticity. Aberrant expression or function of PDZD2 has been implicated in various neurological disorders, making it a promising target for further investigation in research areas such as neuroscience and neurodevelopmental disorders.
By using the PDZD2 Antibody (PACO03681), researchers can accurately detect and analyze PDZD2 protein levels in different cell types and tissues, providing valuable insights into its role in neuronal function and potential implications in disease pathology. This antibody is a valuable tool for researchers aiming to elucidate the molecular mechanisms underlying synaptic transmission and neurological disorders.
Antibody Name:
PDZD2 Antibody
Antibody SKU:
PACO03681
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA, IHC, IF
Recommended Dilutions:
IHC:1:100-1:300, IF:1:200-1:1000
Species Reactivity:
Human, Mouse, Rat
Immunogen:
synthesized peptide derived from the N-terminal region of human PDZK3.
Form:
Liquid
Storage Buffer:
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification Method:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
Synonyms:
PDZD2; AIPC; KIAA0300; PDZK3; PDZ domain-containing protein 2; Activated in prostate cancer protein; PDZ domain-containing protein 3
UniProt Protein Function:
PDZD2: 2 isoforms of the human protein are produced by alternative splicing.Chromosomal Location of Human Ortholog: 5p13.3Cellular Component: endoplasmic reticulum; cytoplasm; extracellular region; intercellular junction; nucleusBiological Process: cell adhesion
UniProt Protein Details:
NCBI Summary:
Proteins containing PDZ domains have been shown frequently to bind the C-termini of transmembrane receptors or ion channels. They have also been shown to bind to other PDZ domain proteins and could possibly be involved in intracellular signalling. The protein encoded by this gene contains six PDZ domains and shares sequence similarity with pro-interleukin-16 (pro-IL-16). Like pro-IL-16, the encoded protein localizes to the endoplasmic reticulum and is thought to be cleaved by a caspase to produce a secreted peptide containing two PDZ domains. In addition, this gene is upregulated in primary prostate tumors and may be involved in the early stages of prostate tumorigenesis. [provided by RefSeq, Jul 2008]
