The PDZD2 Polyclonal Antibody (PAC023166) is a valuable tool for research involving the PDZD2 protein, which plays a role in various cellular functions including cell signaling, protein scaffolding, and membrane organization. This antibody, produced in rabbits, is highly specific to human samples and is validated for use in applications such as Western blotting and immunofluorescence.PDZD2 is a member of the PDZ domain-containing protein family, which are known to be involved in protein-protein interactions and cell signaling pathways. PDZD2 has been linked to neurological disorders and is being studied for its potential role in neuronal development and function.
By using the PAC023166 antibody, researchers can investigate the expression and localization of PDZD2 in different cell types, providing valuable insights into its function and potential implications in disease pathology.Understanding the role of PDZD2 in cellular processes and disease mechanisms is crucial for the development of targeted therapies and diagnostic tools. The PAC023166 antibody offers a reliable tool for researchers to explore the functions of PDZD2 and its involvement in various biological pathways, making it a valuable asset in molecular biology and neuroscience research.
Synthesized peptide derived from internal of human PDZD2.
Form:
Liquid
Storage Buffer:
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Purification Method:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
Immunohistochemistry analysis of paraffin-embedded human prostate carcinoma tissue, using PDZD2 antibody.
Immunofluorescence analysis of HepG2 cells, using PDZD2 antibody.
Background:
Proteins containing PDZ domains have been shown frequently to bind the C-termini of transmembrane receptors or ion channels. They have also been shown to bind to other PDZ domain proteins and could possibly be involved in intracellular signalling. The protein encoded by this gene contains six PDZ domains and shares sequence similarity with pro-interleukin-16 (pro-IL-16). Like pro-IL-16, the encoded protein localizes to the endoplasmic reticulum and is thought to be cleaved by a caspase to produce a secreted peptide containing two PDZ domains. In addition, this gene is upregulated in primary prostate tumors and may be involved in the early stages of prostate tumorigenesis.
Synonyms:
PDZ domain-containing protein 2; PDZ domain-containing protein 3; Activated in prostate cancer protein; Processed PDZ domain-containing protein 2; PDZD2
UniProt Protein Function:
PDZD2: 2 isoforms of the human protein are produced by alternative splicing.Chromosomal Location of Human Ortholog: 5p13.3Cellular Component: endoplasmic reticulum; cytoplasm; extracellular region; intercellular junction; nucleusBiological Process: cell adhesion
UniProt Protein Details:
NCBI Summary:
Proteins containing PDZ domains have been shown frequently to bind the C-termini of transmembrane receptors or ion channels. They have also been shown to bind to other PDZ domain proteins and could possibly be involved in intracellular signalling. The protein encoded by this gene contains six PDZ domains and shares sequence similarity with pro-interleukin-16 (pro-IL-16). Like pro-IL-16, the encoded protein localizes to the endoplasmic reticulum and is thought to be cleaved by a caspase to produce a secreted peptide containing two PDZ domains. In addition, this gene is upregulated in primary prostate tumors and may be involved in the early stages of prostate tumorigenesis. [provided by RefSeq, Jul 2008]
