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PE Anti-Mouse CD45R/B220 Antibody [RA3.3A 1/6.1] (AGEL2215)

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SKU AGEL2215
Product Type Antibody
Antibody Type Monoclonal Antibody
Applications FCM
Reactivity Mouse
Host Species Rat
Isotype Rat IgM, κ
Clone RA3.3A 1/6.1
Conjugation PE
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Description

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PE Anti-Mouse CD45R/B220 Antibody [RA3.3A 1/6.1]

The PE Anti-Mouse CD45R (B220) Antibody (RA3-6B2) is a highly specific and sensitive tool for researchers studying immune cell populations in mice. This monoclonal antibody is designed to target the CD45R (B220) protein, which is a commonly used marker for B cell development and activation. With its fluorescent PE conjugation, this antibody allows for easy and efficient detection of B cells in flow cytometry and other immunofluorescence-based assays. Its specificity for CD45R (B220) ensures accurate identification and analysis of B cell subsets in various tissues and experimental conditions.

This antibody, RA3-6B2, is well-characterized and validated for its performance in detecting B cell populations in mouse models. It is a valuable tool for researchers investigating the role of B cells in immune responses, autoimmune diseases, and cancer. Overall, the PE Anti-Mouse CD45R (B220) Antibody (RA3-6B2) is an essential reagent for enhancing the understanding of B cell biology and its implications in health and disease.

Product Title:PE Anti-Mouse CD45R/B220 Antibody [RA3.3A 1/6.1]
SKU:AGEL2215
Size:25µg, 100µg
Clone No:RA3.3A 1/6.1
Synonyms:B220;
Host Species:Rat
Reactivity:Mouse
Application:FCM
Isotype:Rat IgM, κ
Isotype Control:PE Rat IgM, κ Isotype Control[RTK2118]
Form:Liquid
Conjugation:PE
Recommended Use:Each lot of this antibody is quality control tested by flow cytometric analysis. Please check your vial before the experiment. Since applications vary, the appropriate dilutions must be determined for individual use. We suggest each investigator should titrate the reagent to obtain optimal results [The recommended concentration is 0.1-1 μg/106 cells in 100 μL volume].
Spectrum:Spectrum Image
Gene ID:19264,5788
Storage Buffer:Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer and 1% protein protectant.
Stability & Storage:Keep as concentrated solution. Store at 2~8°C and protected from prolonged exposure to light. Do not freeze. Centrifuge before opening to ensure complete recovery of vial contents. This product is guaranteed up to one year from purchase.
Background:CD45R, also known as B220, is an isoform of CD45. It is a member of the protein tyrosine phosphatase (PTP) family with a molecular weight of approximately 180-240 kD. CD45R is expressed on B cells (at all developmental stages from pro-B cells through mature B cells), activated B cells, and subsets of T and NK cells. CD45R (B220) is also expressed on a subset of abnormal T cells involved in the pathogenesis of systemic autoimmunity in MRL-Faslpr and MRL-Fasgld mice. It plays a critical role in TCR and BCR signaling. The primary ligands for CD45 are galectin-1, CD2, CD3, and CD4. CD45R is commonly used as a pan-B cell marker; however, CD19 may be more appropriate for B cell specificity.

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