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PE Anti-Mouse IL-17A Antibody [17F3] (AGEL3126)

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SKU AGEL3126
Product Type Antibody
Antibody Type Monoclonal Antibody
Applications ICFCM
Reactivity Mouse
Host Species Mouse
Isotype Mouse IgG1, κ
Clone 17F3
Conjugation PE
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Description

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PE Anti-Mouse IL-17A Antibody [17F3]

The PE Anti-Mouse IL-17A Antibody (17F3) is a vital tool for researchers studying the role of IL-17A in immune responses and inflammatory conditions. This antibody, designed for use with mouse samples, specifically targets IL-17A, a cytokine involved in various immune-mediated processes. With high reactivity and specificity, the PE Anti-Mouse IL-17A Antibody (17F3) is validated for use in flow cytometry applications, enabling precise detection and analysis of IL-17A-producing cells in experimental settings.IL-17A is a key player in the regulation of inflammation, autoimmune responses, and host defense against pathogens.

By targeting IL-17A, researchers can gain insights into the mechanisms underlying these processes and explore potential therapeutic interventions for conditions such as autoimmune diseases, infections, and inflammatory disorders. The PE Anti-Mouse IL-17A Antibody (17F3) offers a reliable tool for investigating the role of IL-17A in preclinical studies and advancing our understanding of immune regulation and disease pathogenesis.

Product Title:PE Anti-Mouse IL-17A Antibody [17F3]
SKU:AGEL3126
Size:25µg, 100µg
Clone No:17F3
Synonyms:Interleukin-17A;Il17a;Ctla8;
Host Species:Mouse
Reactivity:Mouse
Application:ICFCM
Isotype:Mouse IgG1, κ
Isotype Control:PE Mouse IgG1, κ Isotype Control[MOPC-21]
Form:Liquid
Conjugation:PE
Recommended Use:Each lot of this antibody is quality control tested by flow cytometric analysis. Please check your vial before the experiment. Since applications vary, the appropriate dilutions must be determined for individual use. We suggest each investigator should titrate the reagent to obtain optimal results [The recommended concentration is 0.1-1 μg/106 cells in 100 μL volume].
Spectrum:Spectrum Image
Swissprot:Q62386
Gene ID:16171
Storage Buffer:Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer and 1% protein protectant.
Stability & Storage:Keep as concentrated solution. Store at 2~8°C and protected from prolonged exposure to light. Do not freeze. Centrifuge before opening to ensure complete recovery of vial contents. This product is guaranteed up to one year from purchase.
Background:The 17F3 monoclonal antibody reacts with mouse IL-17A a 15-20 kDa cytokine expressed by Th17 cells, γδ T cells, iNKT cells, NK cells, LTi cells, neutrophils, and intestinal Paneth cells. IL-17A has pleiotropic effects in immunoregulation and inflammation. It plays an important role in anti-microbial and chronic inflammation by inducing cytokine and chemokine production, neutrophil influx, and the production of antibacterial peptides but it is also an inflammatory mediator in the development of autoimmune diseases including rheumatoid arthritis, asthma, multiple sclerosis, and psoriasis. The 17F3 antibody has been shown to neutralize IL-37A in vivo.

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