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PE Anti-Rat CD44H Antibody [OX-49] (AGEL2432)

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SKU AGEL2432
Product Type Antibody
Antibody Type Monoclonal Antibody
Applications FCM
Reactivity Rat
Host Species Mouse
Isotype Mouse IgG2a, κ
Clone OX-49
Conjugation PE
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Description

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PE Anti-Rat CD44H Antibody [OX-49]

The Rat CD44H Monoclonal Antibody (OX-49) is a powerful tool for researchers studying CD44H, a cell surface glycoprotein involved in cell adhesion and migration. This antibody, produced through the hybridoma technology, specifically targets the rat CD44H antigen and is suitable for various applications such as flow cytometry, immunofluorescence, and immunohistochemistry.CD44H is a key player in cell-cell and cell-matrix interactions, holding significance in processes like lymphocyte homing, wound healing, and cancer metastasis. By using the Rat CD44H Monoclonal Antibody, researchers can investigate the expression and distribution of CD44H in rat tissues and cell lines, aiding in the understanding of its role in physiological and pathological conditions.

With its high specificity and sensitivity, this antibody provides reliable results in experimental settings focusing on cell adhesion, migration, and signaling pathways involving CD44H. Researchers exploring areas such as immunology, oncology, and regenerative medicine will find the Rat CD44H Monoclonal Antibody to be a valuable asset in their research endeavors.

Product Title:PE Anti-Rat CD44H Antibody [OX-49]
SKU:AGEL2432
Size:25µg, 100µg
Clone No:OX-49
Synonyms:Pgp-1; H-CAM; CD44s;CD44H;
Host Species:Mouse
Reactivity:Rat
Application:FCM
Isotype:Mouse IgG2a, κ
Isotype Control:PE Mouse IgG2a, κ Isotype Control[C1.18.4]
Form:Liquid
Conjugation:PE
Recommended Use:Each lot of this antibody is quality control tested by flow cytometric analysis. Please check your vial before the experiment. Since applications vary, the appropriate dilutions must be determined for individual use. We suggest each investigator should titrate the reagent to obtain optimal results [The recommended concentration is 0.1-1 μg/106 cells in 100 μL volume].
Spectrum:Spectrum Image
Swissprot:P26051
Gene ID:12505
Storage Buffer:Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer and 1% protein protectant.
Stability & Storage:Keep as concentrated solution. Store at 2~8°C and protected from prolonged exposure to light. Do not freeze. Centrifuge before opening to ensure complete recovery of vial contents. This product is guaranteed up to one year from purchase.
Background:CD44 is an 80-95 kD cell surface glycoprotein. It is expressed on all leukocytes, endothelial cells, hepatocytes, and mesenchymal cells. It is up-regulated when T cells and B cells are activated. It was reported that CD44 is a valuable marker for memory T cells. CD44 is an adhesion molecule involved in leukocyte adhesion and homing to lymphoid organs. The OX-49 antibody reacts with CD44H (known as CD44s) expressed on most leukocytes, except for a subset of B lymphocytes. The epitope recognized by OX-49 antibody has been mapped to a region on both the standard, CD44s, and the splice variant, CD44v, isoforms of CD44. However it was reported that OX-49 antibody cannot detect the CD44V isoform, possibly due to conformational changes in the epitope.

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