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PE/Cyanine7 Anti-Human CD127/IL-7RA Antibody [A019D5] (AGEL2276)

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SKU AGEL2276
Product Type Antibody
Antibody Type Monoclonal Antibody
Applications FCM
Reactivity Human
Host Species Mouse
Isotype Mouse IgG1, κ
Clone A019D5
Conjugation PE/Cyanine7
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Description

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PE/Cyanine7 Anti-Human CD127/IL-7RA Antibody [A019D5]

The PE-Cyanine7 Anti-Human CD127 (IL-7RA) Antibody (A019D5) from Assay Genie is an essential tool for studying the IL-7 receptor alpha chain (CD127) in human cells. This antibody, validated for flow cytometry applications, offers high specificity and sensitivity in detecting CD127 expression in various cell types.CD127, a critical component of the IL-7 receptor complex, plays a pivotal role in T cell development, survival, and homeostasis. Dysregulation of CD127 expression has been associated with various autoimmune diseases, as well as lymphoid malignancies.

By targeting CD127, researchers can gain insights into the mechanisms underlying these diseases and potentially identify new therapeutic targets.With its reliable performance and broad applicability, the PE-Cyanine7 Anti-Human CD127 (IL-7RA) Antibody (A019D5) is a valuable resource for immunologists, oncologists, and researchers studying T cell biology and immune-related disorders. Trust Assay Genie for high-quality antibodies that drive cutting-edge research in immunology and beyond.

Product Title:PE/Cyanine7 Anti-Human CD127/IL-7RA Antibody [A019D5]
SKU:AGEL2276
Size:20 Tests, 100 Tests, 200 Tests
Clone No:A019D5
Synonyms:Interleukin-7 receptor subunit alpha;IL-7RA;CDw127;CD127;IL-7Rα;
Host Species:Mouse
Reactivity:Human
Application:FCM
Isotype:Mouse IgG1, κ
Isotype Control:PE/Cyanine7 Mouse IgG1, κ Isotype Control[MOPC-21]
Form:Liquid
Conjugation:PE/Cyanine 7
Recommended Use:Each lot of this antibody is quality control tested by flow cytometric analysis. The amount of the reagent is suggested to be used 5 µL of antibody per test (million cells in 100 µL staining volume or per 100 µL of whole blood). Please check your vial before the experiment. Since applications vary, the appropriate dilutions must be determined for individual use.
Spectrum:Spectrum Image
Swissprot:P16871
Gene ID:3575
Storage Buffer:Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer and 1% protein protectant.
Stability & Storage:Keep as concentrated solution. Store at 2~8°C and protected from prolonged exposure to light. Do not freeze. Centrifuge before opening to ensure complete recovery of vial contents. This product is guaranteed up to one year from purchase.
Background:CD127 is a 60-90 kD type I transmembrane glycoprotein also known as IL-7 receptor α chain or IL-7Rα. It forms a heterodimer with the common γ chain (γc or CD132) which is shared with the receptors for IL-2, IL-4, IL-9, IL-13, IL-15, and IL-21. CD127 is expressed on immature B cells through early pre-B stage cells, thymocytes (except CD4/CD8 double positive thymocytes), peripheral T cells, and bone marrow stromal cells. CD127 has been reported to be a useful marker for identifying memory and effector T cells. Studies have shown that CD127 expression is down-modulated on Treg cells. It can be used as a marker for differentiation of Treg and conventional T cells. The ligation of IL-7 with its receptor is important for stimulation of mature and immature T cells as well as immature B cell proliferation and development.

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