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Key Features

PE/Cyanine7 Anti-Mouse CD206 Antibody [C068C2] (AGEL2264)

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SKU AGEL2264
Product Type Antibody
Antibody Type Monoclonal Antibody
Applications FCM
Applications ICFCM
Reactivity Mouse
Host Species Rat
Isotype Rat IgG2a, κ
Clone C068C2
Conjugation PE/Cyanine7
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Description

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PE/Cyanine7 Anti-Mouse CD206 Antibody [C068C2]

The PE-Cyanine7 Anti-Mouse CD206 Antibody (AGEL2264) offered by Assay Genie is a highly specific and reliable tool for research involving CD206, a cell surface protein associated with immune modulation and macrophage function. This antibody, designed for use in flow cytometry and fluorescence imaging applications, is raised against mouse samples, ensuring optimal binding and detection in experimental settings.CD206, also known as macrophage mannose receptor, is a key player in the immune response by mediating phagocytosis and antigen presentation. Its expression on macrophages and dendritic cells highlights its importance in regulating immune responses, making it a focal point for investigations into infectious diseases, inflammation, and immune disorders.

The PE-Cyanine7 Anti-Mouse CD206 Antibody enables precise identification and analysis of CD206-expressing cells, facilitating a deeper understanding of their functions and interactions in various biological contexts.Researchers studying immunology, infection biology, and inflammatory diseases will benefit from the specificity and sensitivity of this antibody in elucidating the roles of CD206 in immune regulation and host defense mechanisms. By uncovering the intricacies of CD206-mediated processes, new therapeutic strategies may be developed to target diseases where immune dysregulation plays a significant role.

Product Title:PE/Cyanine7 Anti-Mouse CD206 Antibody [C068C2]
SKU:AGEL2264
Size:50 Tests, 100 Tests, 200 Tests
Clone No:C068C2
Synonyms:MMR;MR;MRC1;macrophage mannose receptor;mannose receptor ;
Host Species:Rat
Reactivity:Mouse
Application:FCM;ICFCM
Isotype:Rat IgG2a, κ
Isotype Control:PE/Cyanine7 Rat IgG2a, κ Isotype Control[2A3]
Form:Liquid
Conjugation:PE/Cyanine 7
Recommended Use:Each lot of this antibody is quality control tested by flow cytometric analysis. The amount of the reagent is suggested to be used 5 µL of antibody per test (million cells in 100 µL staining volume or per 100 µL of whole blood). Please check your vial before the experiment. Since applications vary, the appropriate dilutions must be determined for individual use.
Spectrum:Spectrum Image
Swissprot:Q61830
Gene ID:17533
Storage Buffer:Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer and 1% protein protectant.
Stability & Storage:Keep as concentrated solution. Store at 2~8°C and protected from prolonged exposure to light. Do not freeze. Centrifuge before opening to ensure complete recovery of vial contents. This product is guaranteed up to one year from purchase.
Background:CD206, also known as mannose receptor (MR), is a 175 kD type I membrane protein. It is a pattern recognition receptor (PRR) belonging to the C-type lectin superfamily. MR is expressed on macrophages, dendritic cells, Langerhans cells, and hepatic or lymphatic endothelial cells. MR recognizes a range of microbial carbohydrates bearing mannose, fucose, or N-acetyl glucosamine through its C-type lectin-like carbohydrate recognition domains, sulfated carbohydrate antigens through its cysteine-rich domain, and collagens through its fibronectin type II domain. MR mediates endocytosis and phagocytosis as well as activation of macrophages and antigen presentation. It plays an important role in host defense and provides a link between innate and adaptive immunity. Recently, MR on lymphatic endothelial cells was found to be involved in leukocyte trafficking and a contributor to the metastatic behavior of cancer cells. It suggests that MR may be a potential target in controlling inflammation and cancer metastasis by targeting the lymphatic vasculature.

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