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PE/Cyanine7 Anti-Mouse CD279/PD-1 Antibody [29F.1A12] (AGEL2257)

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SKU AGEL2257
Product Type Antibody
Antibody Type Monoclonal Antibody
Applications FCM
Reactivity Mouse
Host Species Rat
Isotype Rat IgG2a, κ
Clone 29F.1A12
Conjugation PE/Cyanine7
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Description

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PE/Cyanine7 Anti-Mouse CD279/PD-1 Antibody [29F.1A12]

The PE-Cyanine7 Anti-Mouse CD279 (PD-1) Antibody (29F.1A12) is a critical tool for researchers studying immune regulation and immunotherapy. This antibody, developed by Assay Genie, is specifically designed to target the CD279 protein, also known as Programmed cell death protein 1 (PD-1), which plays a key role in regulating T cell responses and maintaining immune tolerance.Raised in rabbits, this antibody is highly specific and reactive with mouse samples, making it an ideal choice for flow cytometry and immunofluorescence applications. By binding to PD-1, researchers can accurately detect and quantify PD-1 expression on T cells, leading to valuable insights into immune checkpoint pathways and potential therapeutic targets for cancer and autoimmune diseases.

The PE-Cyanine7 Anti-Mouse CD279 (PD-1) Antibody (29F.1A12) from Assay Genie is a valuable tool for researchers seeking to understand the complex interactions of the immune system and develop novel immunotherapies for a range of diseases. With its high specificity and sensitivity, this antibody is a reliable choice for studies in immunology, oncology, and beyond.

Product Title:PE/Cyanine7 Anti-Mouse CD279/PD-1 Antibody [29F.1A12]
SKU:AGEL2257
Size:25µg, 100µg
Clone No:29F.1A12
Synonyms:PD-1; Programmed Death-1;
Host Species:Rat
Reactivity:Mouse
Application:FCM
Isotype:Rat IgG2a, κ
Isotype Control:PE/Cyanine7 Rat IgG2a, κ Isotype Control[2A3]
Form:Liquid
Conjugation:PE/Cyanine 7
Recommended Use:Each lot of this antibody is quality control tested by flow cytometric analysis. Please check your vial before the experiment. Since applications vary, the appropriate dilutions must be determined for individual use. We suggest each investigator should titrate the reagent to obtain optimal results [The recommended concentration is 0.1-1 μg/106 cells in 100 μL volume].
Spectrum:Spectrum Image
Swissprot:Q02242
Gene ID:18566
Storage Buffer:Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer and 1% protein protectant.
Stability & Storage:Keep as concentrated solution. Store at 2~8°C and protected from prolonged exposure to light. Do not freeze. Centrifuge before opening to ensure complete recovery of vial contents. This product is guaranteed up to one year from purchase.
Background:CD279, also known as programmed death-1 (PD-1), is a 50-55 kD glycoprotein belonging to the CD28 family of the Ig superfamily. PD-1 is expressed on activated splenic T and B cells and thymocytes. It is induced on activated myeloid cells as well. PD-1 is involved in lymphocyte clonal selection and peripheral tolerance through binding its ligands, B7-H1 (PD-L1) and B7-DC (PD-L2). It has been reported that PD-1 and PD-L1 interactions are critical to positive selection and play a role in shaping the T cell repertoire. PD-L1 negative costimulation is essential for prolonged survival of intratesticular islet allografts.

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