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Key Features

PE/Cyanine7 Anti-Rat CD8a Antibody [OX-8] (AGEL2196)

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SKU AGEL2196
Product Type Antibody
Antibody Type Monoclonal Antibody
Applications FCM
Reactivity Rat
Host Species Mouse
Isotype Mouse IgG1, κ
Clone OX-8
Conjugation PE/Cyanine7
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Description

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PE/Cyanine7 Anti-Rat CD8a Antibody [OX-8]

The PE-Cyanine7 Anti-Rat CD8a Antibody (OX-8) is a powerful tool for researchers studying immune responses in rats, particularly related to CD8a-positive cells. This antibody is specifically designed for detecting and analyzing CD8a, a marker of cytotoxic T cells, in rat samples. Raised against rat-specific antigens, this antibody offers high specificity and sensitivity in applications such as flow cytometry and immunohistochemistry.CD8a is a key surface marker on cytotoxic T cells, which play a crucial role in immune responses against pathogens and tumorigenesis. By targeting CD8a, researchers can gain insights into the activation and function of cytotoxic T cells in various experimental settings, including antigen-specific responses and immune cell profiling.

The PE-Cyanine7 Anti-Rat CD8a Antibody (OX-8) can be a valuable tool in immunology research, cancer studies, and vaccine development, providing precise detection and quantification of CD8a-expressing cells in rat models. With its reliable performance and specificity, this antibody facilitates in-depth investigations into the intricate mechanisms of immune responses and holds promise for advancing our understanding of immune-related diseases and therapies.

Product Title:PE/Cyanine7 Anti-Rat CD8a Antibody [OX-8]
SKU:AGEL2196
Size:50 Tests, 100 Tests, 200 Tests
Clone No:OX-8
Synonyms:T-cell surface glycoprotein CD8 alpha chain;CD8A;T-lymphocyte differentiation antigen T8/Leu-2;MAL;
Host Species:Mouse
Reactivity:Rat
Application:FCM
Isotype:Mouse IgG1, κ
Isotype Control:PE/Cyanine7 Mouse IgG1, κ Isotype Control[MOPC-21]
Form:Liquid
Conjugation:PE/Cyanine 7
Recommended Use:Each lot of this antibody is quality control tested by flow cytometric analysis. The amount of the reagent is suggested to be used 5 µL of antibody per test (million cells in 100 µL staining volume or per 100 µL of whole blood). Please check your vial before the experiment. Since applications vary, the appropriate dilutions must be determined for individual use.
Spectrum:Spectrum Image
Swissprot:P07725
Gene ID:24930
Storage Buffer:Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer and 1% protein protectant.
Stability & Storage:Keep as concentrated solution. Store at 2~8°C and protected from prolonged exposure to light. Do not freeze. Centrifuge before opening to ensure complete recovery of vial contents. This product is guaranteed up to one year from purchase.
Background:CD8a is a 32 kD glycoprotein also known as T8, Lyt2, Ly-2, and CD8α. CD8a is a member of the immunoglobulin superfamily expressed on most thymocytes, subset of mature T cells, most NK cells, macrophages, and some activated CD4+ T cells (not resting). CD8a forms heterodimers with the CD8β chain (CD8b) on the surface of most thymocytes, while mature peripheral T lymphocytes express almost exclusively the CD8 αβ heterodimer. Intestinal intraepithelial lymphocytes express CD8a without CD8b. CD8 is an antigen co-receptor on T cells that interacts with MHC class I on antigen-presenting cells or epithelial cells. CD8 participates in T cell activation through its association with the T cell receptor complex and protein tyrosine kinase lck (p56lck).

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