Pepsinogen II (PG II) Monoclonal Antibody (CAB22282)
The Pepsinogen II (PG II) Monoclonal Antibody (CAB22282) is a high-quality antibody developed for reliable detection and analysis of target proteins. This monoclonal antibody specifically recognizes PG II and is suitable for various research applications, including immunohistochemistry and ELISA.Pepsinogen II is a precursor enzyme secreted by the stomach's mucous membrane, which plays a key role in the digestive process by eventually converting into pepsin, an enzyme that helps break down proteins.
This antibody is validated for use in IHC-P, ELISA applications and has demonstrated reactivity against Human, Mouse, Rat samples.
Product Name:
Pepsinogen II (PG II) Monoclonal Antibody
SKU:
CAB22282
Size:
20μL, 100μL
Reactivity:
Human, Mouse, Rat
Clone Number:
ARC57717
Conjugate:
Unconjugated
Immunogen:
Recombinant protein (or fragment).This information is considered to be commercially sensitive.
Recommended starting concentration is 1 μg/mL. Please optimize the concentration based on your specific assay requirements.
Synonyms:
PEPC, PGII, Pepsinogen II (PG II)
Cellular Localization:
Secreted.
Calculated MW:
42kDa
Observed MW:
Refertofigures
This gene encodes an aspartic proteinase that belongs to the peptidase family A1. The encoded protein is a digestive enzyme that is produced in the stomach and constitutes a major component of the gastric mucosa. This protein is also secreted into the serum. This protein is synthesized as an inactive zymogen that includes a highly basic prosegment. This enzyme is converted into its active mature form at low pH by sequential cleavage of the prosegment that is carried out by the enzyme itself. Polymorphisms in this gene are associated with susceptibility to gastric cancers. Serum levels of this enzyme are used as a biomarker for certain gastric diseases including Helicobacter pylori related gastritis. Alternate splicing results in multiple transcript variants. A pseudogene of this gene is found on chromosome 1.
Purification Method
Affinity purification
Gene ID
5225
Buffer Information
Store at -20℃. Avoid freeze / thaw cycles. Buffer: PBS with 0.09% Sodium azide,0.05% BSA,50% glycerol,pH7.3.
Immunohistochemistry analysis of paraffin-embedded Human stomach tissue using Pepsinogen II (PG II) Rabbit mAb (CAB22282) at a dilution of 1:1000 (40x lens). High pressure antigen retrieval performed with 0.01M Tris-EDTA Buffer (pH 9.0) prior to IHC staining.
