The PEX3 Antibody (CAB7352) is a high-quality antibody developed for reliable detection and analysis of target proteins. This antibody, developed using rabbits as the host species, demonstrates strong reactivity with human samples, making it a suitable choice for various research applications, such as Western blotting.PEX3 is an essential component of the peroxisomal membrane, contributing to the import and sorting of peroxisomal targeting signal (PTS) proteins. Dysfunction of PEX3 is linked to peroxisome biogenesis disorders, highlighting the importance of studying this protein in the context of metabolic diseases and neurodegenerative disorders.
This antibody is validated for use in WB, ELISA applications and has demonstrated reactivity against Human, Mouse, Rat samples.
Product Name:
PEX3 Antibody
SKU:
CAB7352
Size:
20μL, 100μL
Reactivity:
Human, Mouse, Rat
Conjugate:
Unconjugated
Immunogen:
Recombinant protein (or fragment).This information is considered to be commercially sensitive.
Recommended starting concentration is 1 μg/mL. Please optimize the concentration based on your specific assay requirements.
Synonyms:
TRG18, PBD10A, PBD10B, PEX3
Positive Sample:
Jurkat, Rat liver, Rat brain
Cellular Localization:
Multi-Pass Membrane Protein, Peroxisome Membrane.
Calculated MW:
42kDa
Observed MW:
37kDa
The product of this gene is involved in peroxisome biosynthesis and integrity. It assembles membrane vesicles before the matrix proteins are translocated. Peroxins (PEXs) are proteins that are essential for the assembly of functional peroxisomes. The peroxisome biogenesis disorders (PBDs) are a group of genetically heterogeneous autosomal recessive, lethal diseases characterized by multiple defects in peroxisome function. The peroxisomal biogenesis disorders are a heterogeneous group with at least 14 complementation groups and with more than 1 phenotype being observed in cases falling into particular complementation groups. Although the clinical features of PBD patients vary, cells from all PBD patients exhibit a defect in the import of one or more classes of peroxisomal matrix proteins into the organelle. Defects in this gene are a cause Zellweger syndrome (ZWS).
Purification Method
Affinity purification
Gene ID
8504
RRID
AB_2767889
Buffer Information
Store at -20℃. Avoid freeze / thaw cycles. Buffer: PBS with 0.09% Sodium azide,50% glycerol,pH7.3.
Western blot analysis of various lysates using PEX3 Rabbit pAb (CAB7352) at 1:1000 dilution._Secondary antibody: HRP-conjugated Goat anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution._Lysates/proteins: 25μg per lane._Blocking buffer: 3% nonfat dry milk in TBST._Detection: ECL Enhanced Kit (AbGn00021)._Exposure time: 90s.
