The PGBD2 Polyclonal Antibody (PAC015203) is an essential tool for researchers studying the PGBD2 protein, which plays a key role in regulating transposition activity in the genome. This antibody, produced in rabbits, exhibits strong reactivity with human samples and has been validated for use in Western blotting applications. By specifically binding to PGBD2, researchers can accurately detect and analyze this protein in a variety of cell types, making it an invaluable asset for studies in genetics and genomics.PGBD2 is a DNA transposase that is involved in the movement of DNA segments within the genome, impacting gene expression and genomic stability.
Its function in regulating transposition events makes it a significant target for investigations into genetic disorders, cancer development, and evolutionary biology. Understanding the role of PGBD2 is essential for advancing our knowledge of genome dynamics and the mechanisms underlying genetic diseases, ultimately leading to the development of targeted therapies and treatments.
Antibody Name:
PGBD2 Antibody (PACO15203)
Antibody SKU:
PACO15203
Size:
50ul
Host Species:
Rabbit
Tested Applications:
ELISA, WB
Recommended Dilutions:
ELISA:1:2000-1:5000, WB:1:500-1:2000
Species Reactivity:
Human, Mouse
Immunogen:
Fusion protein of human PGBD2
Form:
Liquid
Storage Buffer:
-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Purification Method:
Antigen affinity purification
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
Gel: 10%SDS-PAGE, Lysate: 40 μg, Lane 1-4: A375 cells, A172 cells, mouse pancreas tissue, human liver cancer tissue, Primary antibody: PACO15203(PGBD2 Antibody) at dilution 1/550, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 20 seconds.
Background:
The piggyBac family of proteins, found in diverse animals, are transposases related to the transposase of the canonical piggyBac transposon from the moth, Trichoplusia ni. This family also includes genes in several genomes, including human, that appear to have been derived from the piggyBac transposons. This gene belongs to the subfamily of piggyBac transposable element derived (PGBD) genes. The PGBD proteins appear to be novel, with no obvious relationship to other transposases, or other known protein families. The exact function of this gene is not known. Two transcript variants encoding different isoforms have been found for this gene.
Synonyms:
PiggyBac transposable element derived 2
UniProt Protein Function:
PGBD2: 2 isoforms of the human protein are produced by alternative splicing.Chromosomal Location of Human Ortholog: 1q44
UniProt Protein Details:
NCBI Summary:
The piggyBac family of proteins, found in diverse animals, are transposases related to the transposase of the canonical piggyBac transposon from the moth, Trichoplusia ni. This family also includes genes in several genomes, including human, that appear to have been derived from the piggyBac transposons. This gene belongs to the subfamily of piggyBac transposable element derived (PGBD) genes. The PGBD proteins appear to be novel, with no obvious relationship to other transposases, or other known protein families. The exact function of this gene is not known. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
