The PGHS-2 Polyclonal Antibody (CAB24438) is a high-quality antibody developed for reliable detection and analysis of target proteins. This antibody, produced in rabbits, is highly specific for human samples and has been validated for Western blot applications. It binds to the PGHS-2 protein, allowing for the detection and analysis of this important enzyme in various cell types.PGHS-2 is a key enzyme involved in the synthesis of prostaglandins, which play crucial roles in inflammation, pain, and various physiological processes. Dysregulation of PGHS-2 has been implicated in diseases such as cancer, inflammation, and cardiovascular disorders.
This antibody is validated for use in WB applications and has demonstrated reactivity against Human samples.
Product Name:
PGHS-2 Polyclonal Antibody
SKU:
CAB24438
Size:
100μL
Reactivity:
Human
Conjugate:
Unconjugated
Immunogen:
Synthetic peptide. This information is considered to be commercially sensitive.
Prostaglandin-endoperoxide synthase (PTGS), also known as cyclooxygenase, is the key enzyme in prostaglandin biosynthesis, and acts both as a dioxygenase and as a peroxidase. There are two isozymes of PTGS: a constitutive PTGS1 and an inducible PTGS2, which differ in their regulation of expression and tissue distribution. This gene encodes the inducible isozyme. It is regulated by specific stimulatory events, suggesting that it is responsible for the prostanoid biosynthesis involved in inflammation and mitogenesis.
Purification Method
Affinity purification
Gene ID
5743
Buffer Information
Store at -20℃. Avoid freeze / thaw cycles. Buffer: PBS containing 50% glycerol, preserved with proclin300 or sodium azide, pH 7.3.
Western blot analysis of various lysates, using PGHS-2 Rabbit pAb (CAB24438) at 1:1000 dilution. Secondary antibody: HRP-conjugated Goat anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25μg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (AbGn00020). Exposure time: 20s.
