The Phospho-CREB1-S133 Monoclonal Antibody (CABP1421) is a high-quality antibody developed for reliable detection and analysis of target proteins. This monoclonal antibody, produced using cutting-edge technology, is highly specific and sensitive in detecting phosphorylation of CREB1 at serine 133, a crucial post-translational modification that regulates its activity.CREB1 plays a vital role in various biological processes, including neuronal plasticity, memory formation, and cell survival. Phosphorylation at serine 133 is known to enhance CREB1's transcriptional activity and influence downstream gene expression. Therefore, the Phospho-CREB1 (S133) Monoclonal Antibody is an essential tool for elucidating the signaling pathways and mechanisms involved in these processes.
This antibody is validated for use in IHC-P, ELISA applications and has demonstrated reactivity against Human, Mouse, Rat samples.
Product Name:
Phospho-CREB1-S133 Monoclonal Antibody
SKU:
CABP1421
Size:
20μL, 100μL
Reactivity:
Human, Mouse, Rat
Clone Number:
ARC60280
Conjugate:
Unconjugated
Immunogen:
Synthetic peptide. This information is considered to be commercially sensitive.
Tested Applications:
IHC-PELISA
Recommended Dilution:
IHC-P
1:50 - 1:200
ELISA
Recommended starting concentration is 1 μg/mL. Please optimize the concentration based on your specific assay requirements.
Synonyms:
CREB, CREB-1, Phospho-CREB1-S133
Cellular Localization:
Nucleus.
Calculated MW:
35kDa
Observed MW:
Refertofigures
This gene encodes a transcription factor that is a member of the leucine zipper family of DNA binding proteins. This protein binds as a homodimer to the cAMP-responsive element, an octameric palindrome. The protein is phosphorylated by several protein kinases, and induces transcription of genes in response to hormonal stimulation of the cAMP pathway. Alternate splicing of this gene results in several transcript variants encoding different isoforms.
Purification Method
Affinity purification
Gene ID
1385
Buffer Information
Store at -20℃. Avoid freeze / thaw cycles. Buffer: PBS containing 50% glycerol and 0.05% BSA, preserved with proclin300 or sodium azide, pH 7.3.
Immunohistochemistry analysis of paraffin-embedded Human colon carcinoma using Phospho-CREB1-S133 Rabbit mAb (CABP1421) at dilution of 1:100 (40x lens). High pressure antigen retrieval performed with 0.01M Citrate buffer (pH 6.0) prior to IHC staining.
Immunohistochemistry analysis of paraffin-embedded Mouse testis using Phospho-CREB1-S133 Rabbit mAb (CABP1421) at dilution of 1:100 (40x lens). High pressure antigen retrieval performed with 0.01M Citrate buffer (pH 6.0) prior to IHC staining.
