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Purified Anti-Human CD32 Antibody [IV-3] (AGEL0291)

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SKU AGEL0291
Product Type Antibody
Antibody Type Monoclonal Antibody
Reactivity Human
Host Species Mouse
Isotype IgG2b
Clone IV-3
Conjugation Unconjugated
Applications FC
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Description

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Purified Anti-Human CD32 Antibody [IV-3]

The Human CD32 Monoclonal Antibody (IV.3) is a vital tool for researchers studying CD32, a cell surface receptor involved in immune response regulation. This monoclonal antibody, generated for target specificity, is optimized for use in various applications such as flow cytometry, immunoprecipitation, and immunohistochemistry.CD32, also known as Fc gamma receptor II, plays a crucial role in the modulation of immune responses by binding to immune complexes and regulating the activation of immune cells. Research into the function and signaling pathways of CD32 is essential for understanding its impact on inflammatory disorders, autoimmune diseases, and infectious diseases. The Human CD32 Monoclonal Antibody (IV.

3) provides researchers with a reliable tool to investigate CD32 expression and function in different cell types and biological systems.This antibody offers high specificity and sensitivity in detecting CD32, enabling precise localization and quantification of the receptor in experimental settings. Its validation for human samples ensures accurate and reproducible results, supporting investigations into the role of CD32 in immune regulation and disease pathogenesis. Researchers in immunology, oncology, and infectious diseases can benefit from the precise targeting and reliable performance of the Human CD32 Monoclonal Antibody (IV.3) in their studies.

Product Title:Purified Anti-Human CD32 Antibody [IV-3]
SKU:AGEL0291
Size:25µg, 100µg
Clone No:IV-3
Synonyms:Low affinity immunoglobulin gamma Fc region receptor II-b;FCGR2B;IgG Fc receptor II-b;CDw32;Fc-gamma RII-b;Fc-gamma-RIIb;FcRII-b;CD32;FCG2; IGFR2;
Host Species:Mouse
Reactivity:Human
Application:FCM
Isotype:Mouse IgG2b, κ
Isotype Control:Purified Mouse IgG2b, κ Isotype Control[MPC-11]
Form:Liquid
Conjugation:Unconjugated
Recommended Use:Each lot of this antibody is quality control tested by flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 1.0 µg per 106 cells in 100 µL volume or 100 µL of whole blood. It is recommended that the reagent be titrated for optimal performance for each application.
Swissprot:P31994
Gene ID:2212
Storage Buffer:Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer.
Stability & Storage:Keep as concentrated solution. Store at 2~8°C and protected from prolonged exposure to light. Do not freeze. Centrifuge before opening to ensure complete recovery of vial contents. This product is guaranteed up to one year from purchase.
Background:CD32 is a 40 kD polymorphic transmembrane glycoprotein also known as FcγRII and FCRII. It is an immunoglobulin superfamily member expressed on monocytes/macrophages, granulocytes, platelets and B cells. There are at least 6 isoforms of CD32 resulting from alternative mRNA splicing. CD32 mediates phagocytosis and oxidative burst in granulocytes, as well as platelet aggregation and immunomodulation. The extracellular domain of CD32 binds to polymeric and aggregated IgG and immune complexes, while the intracellular domain has been reported to associate with SHP-1 (B1 isoform).

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