The Phospho-GRIN2B (Y1474) Polyclonal Antibody (CABP0357) is a valuable tool for researchers studying the GRIN2B protein, a critical component of the NMDA receptor complex involved in synaptic plasticity and excitotoxicity. This antibody, generated in rabbits, specifically targets the phosphorylated form of GRIN2B at tyrosine 1474 and is suitable for Western blot analysis in human samples.GRIN2B phosphorylation at tyrosine 1474 plays a key role in the regulation of NMDA receptor activity, affecting synaptic transmission and plasticity. Dysregulation of GRIN2B phosphorylation has been implicated in various neurological disorders, including schizophrenia, Alzheimer's disease, and epilepsy, making it a promising therapeutic target for drug development.
By detecting and analyzing phospho-GRIN2B (Y1474) levels in different cell types and tissue samples, researchers can gain insights into the molecular mechanisms underlying neuronal function and dysfunction. This antibody is a valuable tool for investigating the role of GRIN2B phosphorylation in neurological disorders and developing novel approaches for their treatment.
Product Name:
Phospho-GRIN2B-Y1474 Rabbit Polyclonal Antibody
SKU:
CABP0357
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human
Immunogen:
A synthetic phosphorylated peptide around Y1474 of human GRIN2B (NP_000825.2).
This gene encodes a member of the N-methyl-D-aspartate (NMDA) receptor family within the ionotropic glutamate receptor superfamily. The encoded protein is a subunit of the NMDA receptor ion channel which acts as an agonist binding site for glutamate. The NMDA receptors mediate a slow calcium-permeable component of excitatory synaptic transmission in the central nervous system. The NMDA receptors are heterotetramers of seven genetically encoded, differentially expressed subunits including NR1 (GRIN1), NR2 (GRIN2A, GRIN2B, GRIN2C, or GRIN2D) and NR3 (GRIN3A or GRIN3B). The early expression of this gene in development suggests a role in brain development, circuit formation, synaptic plasticity, and cellular migration and differentiation. Naturally occurring mutations within this gene are associated with neurodevelopmental disorders including autism spectrum disorder, attention deficit hyperactivity disorder, epilepsy, and schizophrenia.
Purification Method:
Affinity purification
Gene ID:
2904
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of lysates from A431 cells, using Phospho-GRIN2B-Y1474 Rabbit pAb (CABP0357).Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% BSA.
