The Phospho-LIM Domain Kinase 1 (T508) Polyclonal Antibody (CABP0387) is essential for researchers studying the role of Phospho-LIM Domain Kinase 1 (PLK1) in cell cycle regulation and cancer progression. PLK1 is a key regulator of mitosis and is frequently overexpressed in various cancer types, making it a promising target for cancer therapy.This antibody, produced in rabbits, is highly specific to the phosphorylated form of PLK1 at threonine 508 (T508) and is suitable for use in Western blotting and immunohistochemistry applications. It allows for precise detection and quantification of PLK1 phosphorylation levels, providing valuable insights into its activation and function in cancer cells.
With its ability to target the phosphorylated form of PLK1, this antibody is a valuable tool for researchers investigating the molecular mechanisms driving cancer progression and exploring potential therapeutic strategies targeting PLK1 signaling. By understanding the role of PLK1 in cell cycle regulation and cancer development, this antibody contributes to advancements in cancer research and the development of targeted cancer therapies.
Product Name:
Phospho-LIMK1-T508 Rabbit Polyclonal Antibody
SKU:
CABP0387
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
A synthetic phosphorylated peptide around T508 of human LIMK1LIMK1 (NP_002305.1).
There are approximately 40 known eukaryotic LIM proteins, so named for the LIM domains they contain. LIM domains are highly conserved cysteine-rich structures containing 2 zinc fingers. Although zinc fingers usually function by binding to DNA or RNA, the LIM motif probably mediates protein-protein interactions. LIM kinase-1 and LIM kinase-2 belong to a small subfamily with a unique combination of 2 N-terminal LIM motifs and a C-terminal protein kinase domain. LIMK1 is a serine/threonine kinase that regulates actin polymerization via phosphorylation and inactivation of the actin binding factor cofilin. This protein is ubiquitously expressed during development and plays a role in many cellular processes associated with cytoskeletal structure. This protein also stimulates axon growth and may play a role in brain development. LIMK1 hemizygosity is implicated in the impaired visuospatial constructive cognition of Williams syndrome. Alternative splicing results in multiple transcript variants encoding distinct isoforms.
Purification Method:
Affinity purification
Gene ID:
3984
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of lysates from HeLa cells, using Phospho-LIMK1-T508 Rabbit pAb (CABP0387).
