The Phospho-PDGFRB (Y740) Polyclonal Antibody (CABP0556) is a valuable tool for researchers studying the PDGFRB protein, a key player in cell growth and survival signaling pathways. This antibody, produced in rabbits, is highly specific and reactive towards phosphorylated PDGFRB at tyrosine 740 in human and mouse samples, making it ideal for Western blot and immunohistochemistry applications.Phosphorylation of PDGFRB at tyrosine 740 is known to be important for its activation and downstream signaling, influencing cellular processes such as proliferation, differentiation, and migration.
By targeting this specific phosphorylation site, researchers can investigate the regulatory mechanisms of PDGFRB and its role in various physiological and pathological conditions, such as cancer and cardiovascular diseases.The Phospho-PDGFRB (Y740) Polyclonal Antibody (CABP0556) provides a reliable tool for studying the activation status of PDGFRB and its impact on cell behavior, offering valuable insights into potential therapeutic targets for diseases associated with dysregulated PDGFRB signaling.
Product Name:
Phospho-PDGFRB-Y740 Rabbit Polyclonal Antibody
SKU:
CABP0556
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse
Immunogen:
A synthetic phosphorylated peptide around Y740 of human PDGFRB (NP_002600.1).
Cell membrane, Cytoplasmic vesicle, Lysosome lumen, Single-pass type I membrane protein.
Calculated MW:
124kDa
Observed MW:
180kDa
The protein encoded by this gene is a cell surface tyrosine kinase receptor for members of the platelet-derived growth factor family. These growth factors are mitogens for cells of mesenchymal origin. The identity of the growth factor bound to a receptor monomer determines whether the functional receptor is a homodimer (PDGFB or PDGFD) or a heterodimer (PDGFA and PDGFB). This gene is essential for normal development of the cardiovascular system and aids in rearrangement of the actin cytoskeleton. This gene is flanked on chromosome 5 by the genes for granulocyte-macrophage colony-stimulating factor and macrophage-colony stimulating factor receptor; all three genes may be implicated in the 5-q syndrome. A translocation between chromosomes 5 and 12, that fuses this gene to that of the ETV6 gene, results in chronic myeloproliferative disorder with eosinophilia.
Purification Method:
Affinity purification
Gene ID:
5159
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of extracts of NIH/3T3 cells, using Phospho-PDGFRB-Y740 antibody (CABP0556).Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% BSA.
