Description
PKIA Antibody (PACO04711)
The PKIA Polyclonal Antibody (PACO04711) is a high-quality antibody designed for researchers studying PKIA, a key protein kinase that plays a critical role in cellular signaling pathways. This antibody, produced in rabbits, has been validated for use in Western blot applications and is highly reactive with human samples.PKIA, also known as protein kinase A inhibitor alpha, is involved in the regulation of cell growth, differentiation, and survival. By binding to PKIA, this antibody allows for the detection and analysis of PKIA in various cell types, making it a valuable tool for studies in signal transduction, cancer biology, and drug development.
The importance of PKIA in cellular signaling and its potential as a therapeutic target in diseases like cancer and metabolic disorders make it an intriguing molecule for further research. By utilizing the PKIA Polyclonal Antibody, researchers can gain valuable insights into the role of PKIA in health and disease, ultimately leading to the development of novel therapeutic strategies.
| Antibody Name: | PKIA Antibody |
| Antibody SKU: | PACO04711 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, IHC, IF |
| Recommended Dilutions: | IHC:1:100-1:300, IF:1:200-1:1000 |
| Species Reactivity: | Human, Mouse, Rat |
| Immunogen: | synthesized peptide derived from the N-terminal region of human Pki alpha. |
| Form: | Liquid |
| Storage Buffer: | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification Method: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
| Synonyms: | PKIA; PRKACN1; cAMP-dependent protein kinase inhibitor alpha; PKI-alpha; cAMP-dependent protein kinase inhibitor; muscle/brain isoform |
| UniProt Protein Function: | PKIA: Extremely potent competitive inhibitor of cAMP-dependent protein kinase activity, this protein interacts with the catalytic subunit of the enzyme after the cAMP-induced dissociation of its regulatory chains. Belongs to the PKI family. |
| UniProt Protein Details: | Protein type:Inhibitor Chromosomal Location of Human Ortholog: 8q21.13 Cellular Component: cytoplasm; nucleus Molecular Function:cAMP-dependent protein kinase inhibitor activity; protein binding Biological Process: negative regulation of cAMP-dependent protein kinase activity; negative regulation of protein import into nucleus; negative regulation of transcription from RNA polymerase II promoter; regulation of G2/M transition of mitotic cell cycle |
| NCBI Summary: | The protein encoded by this gene is a member of the cAMP-dependent protein kinase (PKA) inhibitor family. This protein was demonstrated to interact with and inhibit the activities of both C alpha and C beta catalytic subunits of the PKA. Alternatively spliced transcript variants encoding the same protein have been reported. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P61925 |
| NCBI GenInfo Identifier: | 5803127 |
| NCBI Gene ID: | 5569 |
| NCBI Accession: | NP_006814.1 |
| UniProt Secondary Accession: | P61925,P04541, Q6IAV2, |
| UniProt Related Accession: | P61925 |
| Molecular Weight: | |
| NCBI Full Name: | cAMP-dependent protein kinase inhibitor alpha |
| NCBI Synonym Full Names: | cAMP-dependent protein kinase inhibitor alpha |
| NCBI Official Symbol: | PKIAÂ Â |
| NCBI Official Synonym Symbols: | PRKACN1Â Â |
| NCBI Protein Information: | cAMP-dependent protein kinase inhibitor alpha |
| UniProt Protein Name: | cAMP-dependent protein kinase inhibitor alpha |
| UniProt Synonym Protein Names: | cAMP-dependent protein kinase inhibitor, muscle/brain isoform |
| Protein Family: | Protein |
| UniProt Gene Name: | PKIAÂ Â |
