The PKP4 Polyclonal Antibody (PACO03066) is a valuable tool for researchers studying PKP4, a protein involved in cell-cell adhesion and signaling pathways. This antibody, produced in rabbits, shows high reactivity with human samples and is validated for use in Western blot applications. By binding to the PKP4 protein, this antibody enables detection and analysis in a variety of cell types, making it ideal for studies in cell biology, developmental biology, and cancer research.PKP4 plays a crucial role in maintaining the integrity of epithelial tissues by facilitating strong cell-cell adhesion and communication.
Dysregulation of PKP4 has been implicated in various diseases, including cancer and skin disorders. Investigating the function of PKP4 can provide insights into the mechanisms underlying these conditions and may lead to the development of targeted therapies.By utilizing the PKP4 Polyclonal Antibody, researchers can delve deeper into the function of PKP4 and its role in cellular processes, ultimately advancing our understanding of disease pathology and potential therapeutic interventions.
Antibody Name:
PKP4 Antibody
Antibody SKU:
PACO03066
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA, WB, IHC
Recommended Dilutions:
WB:1:500-1:2000, IHC:1:100-1:300
Species Reactivity:
Human, Mouse
Immunogen:
synthesized peptide derived from the Internal region of human Plakophilin 4.
Form:
Liquid
Storage Buffer:
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification Method:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
Synonyms:
PKP4; Plakophilin-4; p0071
UniProt Protein Function:
plakophilin 4: an armadillo-like protein of the beta-catenin family. A component of desmosomal plaques and other adhesion plaques and is thought to be involved in regulating junctional plaque organization and cadherin function. Two splice-variant isoforms have been describedProtein type: Cell adhesionChromosomal Location of Human Ortholog: 2q24.1Cellular Component: cell junction; cytoplasm; cytoskeleton; desmosome; intercellular junction; internal side of plasma membrane; midbody; perinuclear region of cytoplasm; plasma membrane; spindle midzone; spindle poleMolecular Function: protein bindingBiological Process: intercellular junction assembly; positive regulation of cytokinesis; positive regulation of GTPase activity
UniProt Protein Details:
NCBI Summary:
Armadillo-like proteins are characterized by a series of armadillo repeats, first defined in the Drosophila 'armadillo' gene product, that are typically 42 to 45 amino acids in length. These proteins can be divided into subfamilies based on their number of repeats, their overall sequence similarity, and the dispersion of the repeats throughout their sequences. Members of the p120(ctn)/plakophilin subfamily of Armadillo-like proteins, including CTNND1, CTNND2, PKP1, PKP2, PKP4, and ARVCF. PKP4 may be a component of desmosomal plaque and other adhesion plaques and is thought to be involved in regulating junctional plaque organization and cadherin function. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2015]
