The PKP4 Polyclonal Antibody (PAC011277) is a valuable tool for research involving PKP4, a protein involved in cell adhesion and communication. This antibody, generated in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications. By specifically binding to the PKP4 protein, this antibody enables the detection and analysis of PKP4 in various cell types, making it ideal for studies in cell biology and cancer research.PKP4, also known as plakophilin-4, plays a crucial role in maintaining cell-cell adhesion and communication in epithelial tissues.
Dysregulation of PKP4 expression has been associated with various diseases, including cancer and skin disorders. By studying the function and regulation of PKP4, researchers can gain insights into the mechanisms underlying these diseases and potentially identify new therapeutic targets.Overall, the PKP4 Polyclonal Antibody is a valuable tool for researchers investigating the role of PKP4 in cell biology and disease, offering high specificity and sensitivity in detecting this important protein.
plakophilin 4: an armadillo-like protein of the beta-catenin family. A component of desmosomal plaques and other adhesion plaques and is thought to be involved in regulating junctional plaque organization and cadherin function. Two splice-variant isoforms have been describedProtein type: Cell adhesionChromosomal Location of Human Ortholog: 2q24.1Cellular Component: cell junction; cytoplasm; cytoskeleton; desmosome; intercellular junction; internal side of plasma membrane; midbody; perinuclear region of cytoplasm; plasma membrane; spindle midzone; spindle poleMolecular Function: protein bindingBiological Process: intercellular junction assembly; positive regulation of cytokinesis; positive regulation of GTPase activity
UniProt Protein Details:
NCBI Summary:
Armadillo-like proteins are characterized by a series of armadillo repeats, first defined in the Drosophila 'armadillo' gene product, that are typically 42 to 45 amino acids in length. These proteins can be divided into subfamilies based on their number of repeats, their overall sequence similarity, and the dispersion of the repeats throughout their sequences. Members of the p120(ctn)/plakophilin subfamily of Armadillo-like proteins, including CTNND1, CTNND2, PKP1, PKP2, PKP4, and ARVCF. PKP4 may be a component of desmosomal plaque and other adhesion plaques and is thought to be involved in regulating junctional plaque organization and cadherin function. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2015]
